ChemicalBook CAS DataBase List 919091-63-7

919091-63-7

Name	RA-9
CAS	919091-63-7
Molecular Formula	C19H15N3O5
MDL Number	MFCD28400615
Molecular Weight	365.34
MOL File	919091-63-7.mol

Chemical Properties

Melting point	230-233 °C(Solv: ethyl ether (60-29-7); acetonitrile (75-05-8))
Boiling point	588.5±50.0 °C(Predicted)
density	1.414±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 4.17 mg/mL (11.41 mM; ultrasonic and warming and heat to 80°C)
form	Solid
pka	5.13±0.20(Predicted)
color	Light yellow to yellow

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312-P330-P501

Hazard Information

Biological Activity

RA-9 is a potent and selective inhibitor of cell-permeable proteasome-associated deubiquitinating enzymes (DUBs) with favorable toxicity and anticancer activity. It selectively induces apoptosis in ovarian cancer cell lines.

in vivo

RA-9 (5 mg/kg; ip; one-day on, two-days off) inhibits human ovarian cancer cell growth in vivo and prolongs survival in a mouse model for ovarian cancer.

< td class="col1 fwb"> Animal Model:

Six-week-old female immunodeficient (NCr nu/nu) mice
Dosage:	5 mg/kg
Administration:	Ip; one-day on, two-days off
Result:	Significant reduction in tumor burden at day 12.

target

storage

Store at -20°C

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Target	Value
DUBs ()