924296-18-4

Potent and selective ubiquitin specific peptidase USP8 deubiquitinase (DUB) inhibitor.

DUB-IN-1 is a potent and selective ubiquitin specific peptidase USP8 deubiquitinase (DUB) inhibitor (IC50 = 850 nM/USP8>100 μM/USP7). DUB-IN-1 inhibits the proliferation (200-800 nM for 24 or 48h; LN229U87MGand T98G cells)invasion (500-800 nM for 48 or 96h; LN229 and T98G cells)and stemness (500-800 nM for 7 or 14 days; LN229 and T98G cells) in GBM cultures.