88419-56-1

clear colorless liquid

2,4,5-Trifluorobenzoyl chloride serves as an acylating reagent in the synthesis of amide and acrylate derivatives. It undergoes condensation with 7-amino-4-(trifluoromethyl)-4a,8a-dihydro-2H-chromen-2-one to form benzamide compounds, and reacts with ethyl butyrimidate hydrochloride under inert atmosphere to yield N-2,4,5-trifluorobenzoylbutanimidic acid ethyl ester. In flow chemistry and batch processes for ciprofloxacin synthesis, it is pumped or added as a stock solution to react with acrylates and LiHMDS[1][2][3].

2,4,5-Trifluorobenzoyl chloride is prepared by refluxing 2,4,5-trifluorobenzoic acid with thionyl chloride in the dark, using catalytic amounts of DMF[3].

[1] Tosso, N. P., Desai, B. K., Oliveira, E. D., Wen, J., Tomlin, J., & Gupton, B. F. (2019). A Consolidated and Continuous Synthesis of Ciprofloxacin from a Vinylogous Cyclopropyl Amide. The Journal of Organic Chemistry, 84(6), 3370–3376. https://doi.org/10.1021/acs.joc.8b03222
[2] Gujjar, K. N., H, U. K. A., Mahesha, M, D. H., Makari, H., S, A., N, C. P. K., & K, L. N. (2026). Insights into fluorinated coumarin derivatives via integrated structural, DFT, and molecular docking studies. Journal of Molecular Structure, 1376, 147028. https://doi.org/10.1016/j.molstruc.2026.147028
[3] Dumur, F., Lepeltier, M., Siboni, H. Z., Xiao, P., Graff, B., Morlet-Savary, F., Lalevée, J., Gigmes, D., & Aziz, H. (2014). Phosphorescent organic light-emitting devices (PhOLEDs) based on 1-methyl-3-propyl-5-(2,4,5-trifluorophenyl)-1H-1,2,4-triazole as the cyclometalated ligand: Influence of the ancillary ligand on the emissive properties. Synthetic Metals, 195, Pages 312-320. https://doi.org/10.1016/j.synthmet.2014.06.021