87726-17-8

Hazard Information

Questions And Answer

• Carbapenems

  Panipenem is a carbapenem antibiotic,it is successfully developed by Japan Sankyo ,it has a broad antimicrobial spectrum , and it has strong antibacterial activity. This product is more stable, and its antibacterial spectrum is similar to imipenem ,it has a strong antibacterial effect on Gram-positive bacteria and negative bacteria, aerobic and anaerobic bacteria ,its effect on Staphylococcus aureus and methicillin-resistant Staphylococcus aureus is superior to that of imipenem, its effect on Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, indole-positive and negative Proteus, Citrobacter, Serratia bacteria is stronger than imipenem, the effect on Pseudomonas aeruginosa is slightly lower than imipenem. To further enhance security, the antibiotic and kidney-protecting agent organic ion transport inhibitors Betamipron as 1:1 ratio are usd for the synthesis of compound preparation, Betamipron does not inhibit the dehydrogenation peptidase,it also has no inhibitory and other pharmacological effects, it only suppresses organic ion transport,it reduces kidney toxicity, it is clinically used for the treatment of bacteremia, sepsis, cholecystitis, liver abscess, peritonitis, inflammation of the eye, otitis media, endocarditis, skin and soft tissue infections, lower respiratory tract infections, genitourinary infections, gynecological infections caused by staphylococcus, streptococcus, enterococcus and other sensitive strains. ;

• Three kinds of carbapenems contrast

  Meropenem, imipenem and panipenem these three carbapenems all have good antibacterial activity on all kinds of G + and G-bacteria bacteria, aerobic and anaerobic bacteria ,they are clinically used for severe infections, mixed infections, nosocomial infections, and immunocompromised infection caused by production enzyme strains, and multi-drug resistant strains and G-mainly bacteria.
  The differences between the three are as follows:
  1, each has different focuses,their anaerobic antibacterial spectrums are similar ; for unfermentable negative bacteria of the aerobic , meropenem is the most active, followed by imipenem, panipenem. For G + bacteria, panipenem is the strongest.
  2, imipenem has the highest incidence of adverse reactions on the central nervous system , meropenem and panipenem are lower.
  3, imipenem is instable to human renal dehydropeptidase,it should to be added with the enzyme inhibitor cilastatin. And meropenem and panipenem are stable to human renal dehydropeptidase. Panipenem have some kidney toxicity, often plus betamethasone in order to reduce nephrotoxicity.
  4, imipenem and panipenem are only available for intravenous, intramuscular meropenem can be used.
  The above information is edited by the chemicalbook of Tian Ye. ;

• Adverse reactions

  Patients allergic to β-lactam antibiotics are banned.
  The elderly, pregnant women, young children and kidney dysfunction patients should use with caution.
  Diarrhea, belching, vomiting, rash.
  Reduce the number of red blood cells and white blood cells, increase eosinophils. ;

Supplier

Related Products