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123-75-1

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Identification

Name
Tetrahydro pyrrole
CAS
123-75-1
Synonyms
1-AZACYCLOPENTANE
AKOS BBS-00003603
AZACYCLOPENTANE
FEMA 2523
FEMA 3523
LABOTEST-BB LTBB000397
PRD
PRL
PYRROLIDINE
TETRAHYDROPYRROLE
TETRAMETHYLENEIMINE
Azolidine
Butylenimine
perhydroazole
Perhydropyrrole
Prolamine
Pyrrole, tetrahydro-
Pyrrolidene
Pyrrolidin
pyrrolidinering
EINECS(EC#)
204-648-7
Molecular Formula
C4H9N
MDL Number
MFCD00005249
Molecular Weight
71.12
MOL File
123-75-1.mol

Chemical Properties

Appearance
colourless to pale yellow liquid with a penetrating
mp 
-63 °C
bp 
87-88 °C(lit.)

density 
0.866
vapor density 
2.45 (vs air)

vapor pressure 
128 mm Hg ( 39 °C)

refractive index 
n20/D 1.443(lit.)

FEMA 
3523
Fp 
37 °F

storage temp. 
Flammables area
Stability:
Stable; flammable. Incompatible with strong acids, strong oxidizing agents.
Sensitive 
Air Sensitive
Detection Methods
GC
Merck 
14,8015
BRN 
102395
CAS DataBase Reference
123-75-1(CAS DataBase Reference)
NIST Chemistry Reference
Pyrrolidine(123-75-1)
Storage Precautions
Store under nitrogen
EPA Substance Registry System
123-75-1(EPA Substance)

Safety Data

Hazard Codes 
F,T,C
Risk Statements 
R11:Highly Flammable.
R22:Harmful if swallowed.
R23:Toxic by inhalation.
R34:Causes burns.
R35:Causes severe burns.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R20/22:Harmful by inhalation and if swallowed .
Safety Statements 
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S33:Take precautionary measures against static discharges .
RIDADR 
UN 1922 3/PG 2

WGK Germany 
2

RTECS 
UX9650000


34
HazardClass 
3
PackingGroup 
II
HS Code 
29339900
Safety Profile
Poison by ingestion and intravenous routes. Moderately toxic by inhalation. Dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits hghly toxic fumes of NOx.
Hazardous Substances Data
123-75-1(Hazardous Substances Data)

Raw materials And Preparation Products

Hazard Information

General Description
A colorless to pale yellow liquid with an ammonia-like odor. Flash point 37°F. Density 0.85 g/cm3. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion.
Reactivity Profile
PYRROLIDINE(123-75-1) neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. An explosion occurred when a mixture of PYRROLIDINE(123-75-1), benzaldehyde, and propionic acid was heated in an attempt to form porphyrins.
Air & Water Reactions
Highly flammable. Very soluble in water.
Hazard
Flammable, dangerous fire risk. Toxic by ingestion and inhalation.
Health Hazard
May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire Hazard
Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Material Safety Data Sheet(MSDS)

msds information
pyrrolidine(123-75-1).msds

Questions And Answer

Chemical Properties

Pyrrolidine appears as a colorless to pale yellow liquid with an ammonia-like odor. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion.
Pyrrolidine is a cyclic amine whose five-membered ring contains four carbon atoms and one nitrogen atom; the parent compound of the pyrrolidine family. It is a saturated organic heteromonocyclic parent, a member of pyrrolidines and an azacycloalkane. It is a conjugate base of a pyrrolidinium ion.


Production
Pyrrolidine can be produced from butanediol and ammonia, e.g., over an aluminum thorium oxide catalyst at 300℃ or over a nickel catalyst at 200℃ and 20 MPa under hydrogenation conditions. It can also be produced from tetrahydrofuran and ammonia over aluminum oxide at 275-375℃.Production can be obtained by reaction of 1,4-dihydroxyalkanes with amines in the presence of dehydrating agents at elevated temperatures or by reaction of primary amines with 1,4-dihaloalkanes. The dry distillation of 1,4-butanediamine dihydrochloride also generates pyrrolidine.
Pyrrolidine
Pyrrolidine is also known as tetrahydro pyrrole, and it is colorless to pale yellow liquid with a pungent ammonia odor, smoke in air, and toxic. The relative density is 0.8618, the boiling point is 88~89℃, refractive index is 1.4402 (28℃). It is strong alkaline, miscible with water, soluble in alcohol, ether and chloroform.
Pyrrole can synthesize pyrrolidine by catalytic hydrogenation, pyrrolidine present in tobacco and carrot leaves, and it is natural substances, the molecular structure of pyrrolidine is cyclic secondary amine, which is generally the same with the reaction of amine. Pyrrolidine is an important organic chemical raw material, it can be used for drug preparation, fungicides and insecticides.
Preparation:
1. 1,4-butanediol as the raw material, dehydrate to tetrahydrofuran, and then reacte with ammonia, then pyrrolidine can be obtained.
2. Furan as raw material, react with ammonia in the catalyst at 400℃ can obtain tetrahydro pyrrole.
3. The 1,4-dichloro-butane as raw material, react with ammonia, pyrrolidine can be obtained.
4. Pyrrole as raw material, with the catalyst of rhodium or ruthenium, with the reaction of reduction can obtain .
The above information is edited by the chemicalbook of Wang Xiaodong.
Chemical Properties
It is colorless, transparent liquid with special smell. When exposed to light or moist air, it can turn yellow. It can be soluble in water, ethanol. It is corrosive and flammable. Boiling point is 87.0~89.0℃.
Uses
Pharmaceutical raw materials, organic synthesis, special organic solvents.
It can be used for the preparation of drugs, fungicides, insecticides, etc.
Category
Flammable liquid.
Toxicity grading
Highly toxic.
Acute toxicity
Oral-rat LD50: 300 mg/kg; Oral-Mouse LD50: 450 mg/kg.
Flammability hazard characteristics
When exposed to fire, high temperature, oxidant, it is flammable; when heat, toxic nitric oxide gas can produce.
Storage Characteristics
Treasury ventilation low-temperature drying; oxidants, acids stored separately.
Extinguishing agent
Dry, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent.
Occupational standards
STEL 0.1 mg /m.

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