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104987-11-3

Name Tacrolimus
CAS 104987-11-3
EINECS(EC#) 1308068-626-2
Molecular Formula C44H69NO12
MDL Number MFCD00869853
Molecular Weight 804.02
MOL File 104987-11-3.mol

Chemical Properties

Appearance White Crystalline Solid
Melting point  113-115°C
Boiling point  871.7±75.0 °C(Predicted)
density  1.19±0.1 g/cm3(Predicted)
Fp  2℃
storage temp.  −20°C
solubility  DMSO: >3 mg/mL
form  solid
pka 9.97±0.70(Predicted)
color  white
Water Solubility  Freely soluble in DMSO or ethanol. Poorly soluble in water.Soluble in dimethyl sulfoxide, ethanol, water, acetone, chloroform, ethyl acetate, ether, methanol and dimethyl formamide.
Usage An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca
BCS Class 2
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
InChIKey QJJXYPPXXYFBGM-LFZNUXCKSA-N
CAS DataBase Reference 104987-11-3(CAS DataBase Reference)

Safety Data

Hazard Codes  T,Xi
Risk Statements 
R25:Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  KD4201200
HazardClass  6.1
HS Code  38220090
Hazardous Substances Data 104987-11-3(Hazardous Substances Data)

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