ChemicalBook CAS DataBase List 873546-31-7

873546-31-7

Name	T-2307
CAS	873546-31-7
Molecular Formula	C25H35N5O2
MDL Number	MFCD32640691
Molecular Weight	437.58
MOL File	873546-31-7.mol

Chemical Properties

Boiling point	616.3±65.0 °C(Predicted)
density	1.21±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 50 mg/mL (114.26 mM; ultrasonic and adjust pH to 3 with HCl)
form	Solid
pka	12.50±0.50(Predicted)
color	Off-white to light brown

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H302-H335-H319
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501

Hazard Information

Uses

T-2307, an arylamidine, has antifungal activities in vitro and in vivo. T-2307 exhibits broad-spectrum activity against clinically significant pathogens, including Candida species (MIC range, 0.00025 to 0.0078 μg/ml), Cryptococcus neoformans (MIC range, 0.0039 to 0.0625 μg/ml), and Aspergillus species (MIC range, 0.0156 to 4 μg/mL) [1].

in vivo

In mouse models of disseminated candidiasis, cryptococcosis, and aspergillosis, the ED₅₀ of T-2307 were 0.00755, 0.117, and 0.391 mg/kg, respectively^[1].

Animal Model:	4-week-old specific-pathogen-free ICR strain male mice bearing systemic infections with?Candida albicans, Cryptococcus neoformans, and?Aspergillus fumigatus^[1].
Dosage:	0.001, 0.1, 1 mg/kg
Administration:	Subcutaneously administered; once a day for 7 days, beginning at 2 h after the infection.
Result:	In the systemic infection caused by?Candida albicans, all the control mice died by day 6. Mortality was significantly delayed in mice that were administered T-2307 at a dose of 0.01 mg/kg?compared with that in the control mice. The calculated ED₅₀s of T-2307were 0.00755 mg/kg. In the systemic infection caused by?Cryptococcus neoformans, all the control mice died by day 9. Mortality was significantly delayed in mice administered T-2307 at a dose of 0.1 mg/kg?compared with that in the control mice. The calculated ED₅₀s of T-2307 were 0.117 mg/kg. In the systemic infection caused by?Aspergillus fumigatus, all the control mice died by day 6. Mortality was significantly delayed in mice that were administered T-2307 at a dose of 1 mg/kg compared with that in the control mice. The calculated ED₅₀s of T-2307 were 0.391 mg/kg.

storage

Store at -20°C

References

[1] Junichi Mitsuyama, et al. ?In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. Antimicrob Agents Chemother.?2008 Apr;52(4):1318-24. DOI:10.1128/AAC.01159-07
[2] Eio Yamada, et al. ?T-2307 shows efficacy in a murine model of Candida glabrata infection despite in vitro trailing growth phenomena. Antimicrob Agents Chemother.?2010 Sep;54(9):3630-4. DOI:10.1128/AAC.00355-10

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