83857-96-9

2-Butyl-4-chloro-5-formylimidazole(83857-96-9) is an API intermediate used as an intermediate for the anti-hypertensive drug Chlosartan. It can be used in the chemical manufacture of many APIs and advanced intermediates. With the help of this chemical, a number of other chemicals can be manufactured that have further applications in industries such as Losartan manufacturing.

2-Butyl-4-chloro-5-formylimidazole is Yellow Solid

2-Butyl-4-chloro-5-formylimidazole(83857-96-9) is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists

2-Butyl-4-chloro-1H-imidazole-5-carboxaldehyde (Losartan EP Impurity D,83857-96-9) is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists. Losartan USP Related Compound A.

The Journal of Organic Chemistry, 64, p. 8084, 1999 DOI: 10.1021/jo9824910

2-Butyl-4-chloro-5-formylimidazole(83857-96-9) was synthesised as follows: Performing condensation reaction of pentamidine hydrochloride with glyoxal and controlling the pH value of the system in the range of 6.0-7.5; after the reaction terminates, arousing dehydration reaction of the compound of formula III, thereby obtaining 2-butyl-1H-imidazole-5(4H)-ketone; and finally, reacting 2-butyl-1H-imidazole-5(4H)-ketone with N,N-dimethylformamide in the presence of phosphorus oxychloride, thereby obtaining 2-butyl-4-chloro-5-formylimidazole.

2-Butyl-4-chloro-5-formylimidazole is soluble in DMF, DMSO, Ethanol and Methanol.