8018-01-7

Mancozeb is a mixture of Maneb (M163500) and Zineb, a manganese and zinc (1:1) complex mixture with the ethylene bis(dithiocarbamate) anionic ligand. Mancozeb is a foliate fungicide used to protect cr ops in agriculture. Mancozeb has a broader and more effective fungacidal activity than either of its component on their own. Mancozeb also significantly enhances the copper activity against several ba cteriosis.

Fungicide.

Mancozeb is a dithiocarbamate fungicide. It is used to control a wide variety of fungal diseases, including potato blight, leaf spot, scab (on apples and pears), and rust (on roses). It is used on fruits, vegetables, nuts and field crops, and many more. It is also used as a seed treatment of cotton, potatoes, corn, safflower, sorghum, peanuts, tomatoes, flax, and cereal grains

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions) if breathing has stopped, and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. If victim is conscious and able to swallow, have victim drink 4 to 8 oz of water. Do not induce vomiting.

UN2771 Dithiocarbamate and Thiocarbamate pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1- Poisonous materials.

Combustible material. Dust may form explosive mixture in air. Decomposes in temperatures above 170C. Keep away from water, acid, oxidizing materials. Dithiocarbamate esters are combustible. They react violently with powerful oxidizers such as calcium hypochlorite. Poisonous gases are generated by the thermal decomposition of Dithiocarbamate compounds, including carbon disulfide, oxides of sulfur, oxides of nitrogen, hydrogen sulfide, ammonia, and methylamine. Thio and dithiocarbamates slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids. Flammable gases are generated by the combination of dithiocarbamate with aldehydes, nitrides, and hydrides. Dithiocarbamate are incompatible with acids, peroxides, and acid halides. Corrosive to iron, copper brass, and zinc metals, especially in the presence of moisture. Contact with lime, moisture can cause decomposition. Decomposes on prolonged storage. Degradation produces ethylene thiourea.

Mancozeb is a fungicide of the ethylene-bis-dit-hiocarbamate group. It is present in Rondo-M with pyrifenox. Occupational exposure occurs mainly in agricultural workers, in vineyard workers or in florists.

Grayish-yellow powder

Disposal Method Suggested: Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number N450, must conform to USEPA regulations for storage, transportation, treatment, and disposal of waste. Dispose of waste material as hazardous waste using a licensed disposal contractor to an approved landfill. Dispose of contents and container to an approved waste disposal plant. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. All federal, state, and local environmental regulations must be observed. Do not discharge into drains or sewers. A potential candidate for liquid injection incineration at a temperature range of 650 to 1600C and a residence time 0.1 to 2 seconds. Also, a potential candidate for rotary kiln incineration at a temperature range of 820 to 1600C and residence times of seconds for liquids and gases, and hours for solids.

Mancozeb is commercially produced through the reaction of ethylene bisdithiocarbamate (EBDC) with manganese and zinc salts, forming a coordination complex that gives the fungicide its broad-spectrum activity. The synthesis typically involves mixing sodium EBDC with manganese sulfate and zinc sulfate under controlled pH and temperature conditions, followed by filtration, drying, and milling to produce a fine powder.

Fungicide: Mancozeb is used to control a wide variety of fungal diseases, including potato blight, leaf spot, scab (on apples and pears), and rust (on roses). It is used on fruits, vegetables, nuts and field crops, and many more. It is also used as a seed treatment of cotton, potatoes, corn, safflower, sorghum, peanuts, tomatoes, flax, and cereal grains.

ACROBAT® (mancozeb + dimethomorph); ASHLAND SOLACE® (cymoxanil + mancozeb); CARMAZINE®; CUPROFIX®; DITHANE®; EMCARB® (mancozeb + carbendez); EMTHANE M-15®; EVOLVE®; F 2966®; FORE®; FORMEC®; GAUCHO® (imidacloprid + mancozeb); GAVEL® (mancozeb + zoxamide); GREEN-DAISEN M®; KARAMATE®; KENCOZEB®; MANCOFOL®; MANOSEB®; MANTOX®; MANZATE 200®; MANZEB®; MANZIN 80®; MARZIN®; MAXIM®; MILOR®; NEMISPOR®; PACE® fungicide (mixture of mancozeb and metalaxyl); PENNCOZEB®; POLICAR®; TRIZIMAN®; TRIZIMAN-D®; VONDOZEB PLUS®; ZIMANAT®; ZIMMAN-DITHANE®; ZIMANEB®

Broad-spectrum, non-systemic, contact with protective action, acts by distrupting lipid metabolism. Multi-site activity.

Plant. Undergoes metabolism in plants to ethyl thiourea, ethylene thiuram disulfide, thiuram monosulfide and sulfur (Hartley and Kidd, 1987).
Chemical/Physical. Decomposes in acids releasing carbon disulfide. In oxygenated waters, mancozeb degraded to ethylene thiuram monosulfide, ethylene diisocyanate, ethylene thiourea, ethylenediamine and sulfur (Worthing and Hance, 1991).

Mancozeb is a mixture containing maneb and zineb as the active ingredients. Maneb and zineb and other alkylenebis( dithiocarbamate) fungicides are degraded and metabolised via a common pathway. The primary degradation reaction of maneb and zineb in water, soil, plants and animals involves the initial dissociation of the metal complex and decomposition to numerous degradation products including ethylenethiourea (ETU) and ethyleneurea (EU) as major products. See zineb and maneb summaries for detailed descriptions.

Store at -20°C

Mancozeb (1) was readily hydrolysed in neutral and alkaline solution with DT9 values of 20 days (pH 5), 17 hours (pH 7) and 34 hours (pH 9) (PM). See zineb and maneb summaries for the hydrolytic degradation pathway.

The mechanism of toxicity for MZ is similar to other EBDC fungicides like maneb. EBDC are able to modify and inactivate redox-sensitive proteins. Because of the thiol reactivity of these compounds, redox-sensitive processes like transcription, translation, and other metabolic processes can be altered, resulting in cytotoxicity. It is due to this multitarget mode of action that MZ and other EBDC compounds are used in fungicide resistance management programs. In contrast to other fungicidal agents, in over 40 years of use, resistance to any of the EBDC compounds has never developed. MZ has also been reported to cause oxidative stress, DNA damage, and apoptosis in rat cells. Additionally, like all EBDC, MZ can act as a chelating agent, allowing it to interfere with enzymes that contain metals which are essential for activity, like dopamine b-hydroxylase.

Fungicide