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796-42-9

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Identification

Name
N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
CAS
796-42-9
Synonyms
AS8351
NSC51355
NSC-51355
NSC 51355
AS8351;AS 8351;NSC51355;NSC 51355;NSC-51355
N'-[(2-Hydroxy-1-naphthyl)methylene]isonicotinohydrazide
N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
N-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]pyridine-4-carbohydrazide
N'-[(2-hydroxynaphthalen-1-yl)methylidene]pyridine-4-carbohydrazide
4-Pyridinecarboxylic acid, 2-[(2-hydroxy-1-naphthalenyl)methylene]hydrazide
Molecular Formula
C17H13N3O2
MOL File
796-42-9.mol
Molecular Weight
291.3

Chemical Properties

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in DMSO (45 mg/ml); ethanol (10 mg/ml with warming)
form 
solid
color 
Yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Hazard Information

Description
AS-8351 is a histone demethylase inhibitor. It has been used in combination with CHIR99021 (Item No. 13122), A 83-01 (Item No. 9001799), BIX01294 (Item No. 13124), SC-1 (Item No. 10009557), Y-27632 (Item No. 10005583), OAC2 (Item No. 14103), SU 16f (Item No. 19555), and JNJ-10198409 (Item No. 10008131) to induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.
References
1) Cao et al. (2016), Conversion of human fibroblasts into functional cardiomyocytes by small molecules; Science, 352 1216

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