70018-51-8

Ro 13-6438 (70018-51-8) is a selective inhibitor of phosphodiesterase III (PDE III, IC50 = 0.6 μM).

Cardiotonic.

Quazinone (Ro 13-6438) is a phosphodiesterase inhibitor and novel cardiotonic agent with vasodilating properties.

1) Eigenmann et al. (1984) Cardiovascular profile of Ro 13-6438, a novel positive inotropic agent with vasodilating properties; J. Cardiovasc. Pharmacol., 6 511 2) Holck et al. (1984) Studies on the mechanism of positive inotropic activity of Ro 13-6438, a structurally novel cardiotonic agent with vasodilating properties; J. Cardiovasc. Pharmacol. 6 520