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Questions And Answer

• Description

  Ethylhexylglycerin is also named as 3-(2-Ethylhexoxy)propane-1,2-diol or octoxyglycerin. It is a glyceryl ether. It is used as a weak preservative, as skin conditioning agent with effective wetting ability. It is used with phenoxyethanol in cosmetics to obtain better protection against microbial growth.;

• Chemical Properties

  Ethylhexylglycerin is a glycerol monoalkylether of defined structure and high purity,with a 2-ethylhexyl group bound to the primary hydroxyl function of the glycerol molecule. Due to the fact that it is a crystal-clear,colourless liquid with a slightly characteristic odour it is well suited for the use in cosmetic products. Although it is less soluble in water(<0.1% at 25℃),it is more easily soluble in most common cosmetic alcohols and glycols as well as oils.Ethylhexylglycerin is rather stable, e.g. against hydrolysis and elevated temperatures and compatible with cosmetic ingredients.
  Ethylhexylglycerin is globally approved and as a new substance accords with the European legislation listed on the ELINCS file.
  International Approvals
  Europe / USA: INCl name: Ethylhexylglycerin
  Australia: AICS/NICNAS(NA/966)，TGA
  Canada:DSL
  Japan:
  ENCS as glycerin monoalkyl(or alkenyl,C8-C24)ether(No.: 2-414)
  CLS 199;

• Uses

  Ethylhexylglycerin is a natural preservative, used as an alternative to parabens products. It is derived from natural glycerin. Also used as a deodorizer and skin conditioner.
  Ethylhexylglycerin is a glyceryl ether and serves as an emollient solvent and a fixative with antimicrobial properties, and it is reported to enhance uptake of preservatives in microorganisms. It is often used as an alternative to parabens. The International Nomenclature of Cosmetic Ingredients name is Ethylhexylglycerin, and the chemical formula and synonym names are shown in Figure 1. Ethylhexylglycerin is a colorless to pale viscous liquid. It is reported to be used at a concentration up to 2% in leave-on products and 8% in rinse-off products. It is manufactured and marketed by Schu¨lke & Mayr GMBH, Norderstedt, Germany, under the trade name, Sensiva SC50, which is greater than 99% pure. Ethylhexylglycerin is found in many cosmetic products, that is, antiaging creams, sunscreens, eye shadows, eye creams, lip gloss, deodorants, facial moisturizers, and various types of cleansers.;

• Safety

  With an EWG score of 1 and a rating of GOOD from Paula’s Choice, ethylhexylgylcerin is deemed to be very safe and a non-irritant.
  Ethylhexylglycerin is a topical skin care ingredient and deodorizing agent, often indicated as a conditioning ointment in the treatment of eczema. It can also be a surfactant and preservative-enhancer and can be found as a substituent for parabens. Ethylhexylglycerin is commonly found in baby products or cosmetics marketed as “hypoallergenic” or “formaldehyde free”.
  Ethylhexylglycerin has been reported to cause dermatitis and skin irritation.
  www.cir-safety.org
  What Is Ethylhexylglcerin & Is It Safe?;

• Toxicity evaluation

  The oral toxicity of ethylhexylglycerin (Sensiva® SC 50, in polyethylene glycol 400) at doses of 100, 500, and 1,500 mg/kg was evaluated in a 28-day study using groups of 10 rats of an unspecified strain. The test substance was administered at a dose volume of 5 ml/kg.There were no treatment-related mortalities. Body weight development was retarded in mid- and high-dose groups, and this finding was accompanied by a non-statistically significant reduction in food intake when compared to the control (polyethylene glycol 400) group. Both eye and ear functions remained unchanged during the study, and increased salivation (dose not stated) was the only clinical symptom observed. Hematological parameters were unaffected by treatment; however, serum analyses indicated changes in aminotransferase (above normal) in high-dose rats. Urinalysis and necropsy findings were unremarkable.;

• Reference

  W. Beilfuss, M. Leschke, K. Weber, A New Concept to Boost the Preservative Efficacy of Phenoxyethanol, SÖFW-Journal, 2005, vol. 131 ;

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