Chemical Properties
colourless liquid
General Description
Colorless liquid.
Reactivity Profile
PHENYL GLYCIDYL ETHER(122-60-1), an ether, can act as a base. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.
Air & Water Reactions
Ethers tend to form unstable peroxides when exposed to oxygen. Ethyl, isobutyl, ethyl tert-butyl, and ethyl tert-pentyl ether are particularly hazardous in this respect. Ether peroxides can sometimes be observed as clear crystals deposited on containers or along the surface of the liquid. Slightly soluble in water.
Potential Exposure
PGE is used to increase storage time and stability of halogenated compounds; as a reactive diluent in uncured epoxy resins to reduce the viscosity of the uncured system for ease in casting; adhesive, and laminating applications. NIOSH once estimated that 8000 workers are potentially exposed to PGE.
Fire Hazard
This chemical is probably combustible.
First aid
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, amines, and curing agents. PGE can presumably form explosive peroxides
Description
This monoglycidyl derivative is a reactive diluent in
epoxy resins of the bisphenol A type. It is a component
of epoxy paints, epoxy glues, and epoxy resins.
Sensitization was observed in many professions, such
as in construction workers, marble workers, ceramic
workers, and in a shoemaker.
Waste Disposal
Concentrated waste containing no peroxides-discharge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxidesperforation of a container of the waste from a safe distance followed by open burning.
Uses
2-Phenylglycidyl ether is an organic synthesis; chemical intermediate with high solvency for halogenated materials; reactive diluent of epoxy-resin systems; forms chemical bonds with the resin during cure and accelerates the curing process.
Uses
Chemical intermediate with high solvency
for halogenated materials
Uses
Phenyl glycidyl ether (PGE) is used as anintermediate in organic syntheses.
Definition
ChEBI: Phenyl glycidyl ether is an aromatic ether.
Production Methods
PGE is synthesized by condensation of phenol with epichlorohydrin,
with subsequent dehydrochlorination with caustic
to form the epoxy ring.
Health Hazard
PGE is a toxic compound exhibiting moderate irritant action and carcinogenicity inanimals. Application of 0.25 mg resulted insevere eye irritation in rabbits, while 500 mgcaused moderate skin irritation over a periodof 24 hours. Prolonged or repeated contactcan cause moderate irritation and skin sensitization in humans.
The symptoms of its toxicity in animalswere depression of the central nervous system and paralysis of the respiratory tract.Prolonged exposure caused changes in thekidney, liver, thymus, and testes, and lossof hair in rats. The toxicity of this compound in humans is low and the health hazardcan arise primarily from its skin-sensitizationaction.
LD50 value, oral (mice): 1400 mg/kg
DGE showed carcinogenicity in rats, causingnasal cancer.
Carcinogenicity
Chronic exposure of rats to 1 or 12ppm
6 hours/day, 5 days/week for 2 years caused an
increased incidence of rhinitis, squamous metaplasia,
and epidermal carcinomas of the nasal
cavity.4 The IARC has determined that there is
sufficient evidence for the carcinogenicity of
PGE in animals and that it is possibly carcinogenic
to humans.
Toxics Screening Level
The IRSL of Phenyl glycidyl ether is 0.1 μg/m3 with annual averaging.
