ChemicalBook CAS DataBase List 68291-98-5

68291-98-5

Name	Zonisamide sodium salt
CAS	68291-98-5
Molecular Formula	C8H7N2NaO3S
MDL Number	MFCD00865316
Molecular Weight	234.21
MOL File	68291-98-5.mol

Chemical Properties

storage temp.	Store at -20°C
solubility	H2O: >5mg/mL
form	powder
color	white to beige
Water Solubility	H2O: >5mg/mL
InChI	1S/C8H7N2O3S.Na/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7;/h1-4H,5H2,(H-,9,11,12);/q-1;+1
InChIKey	ZVBIRPKGWOVBLG-UHFFFAOYSA-N
SMILES	[Na]NS(=O)(=O)Cc1noc2ccccc12

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312-P330-P501
Hazard Codes	Xn
Risk Statements	22 less more
WGK Germany	3
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral

Hazard Information

Uses

Zonisamide Sodium Salt can be used in biological study of neuroprotective effects of zonisamide target astrocyte. It shows neuroprotection by increasing glutathione, cystine/glutamate exchange transporter expression in mouse CNS catecholaminergic, astrocyte and rat glioma cell and mouse model of 6-OHDA induced hemi-Parkinson''s disease

Biochem/physiol Actions

Zonisamide sodium salt is an anti-epileptic. It is effective in various animal epilepsy models and humans with both partial and generalized epileptic seizures. Zonisamide sodium salt also scavenges nitric oxide (NO).

in vivo

Zonisamide sodium (40 mg/kg; i.p.; single daily for 14 days) prevents seizures in FeCl₃-induced chronic amygdalar seizures model^[2].
Zonisamide sodium (14, 28, 56 mg/kg; i.p.; single daily for 6 weeks) alleviates cardiac hypertrophy and improved cardiac function in rats subjected to AAC (abdominal aortic constriction)^[3].
Zonisamide sodium (14, 28, 56 mg/kg; i.p.; single daily for 6 weeks) upregulates Hrd1 expression and accelerates ERAD in the hearts of AAC rats^[3].

Animal Model:	Male Wistar rats (200-250 g; FeCl₃-induced chronic amygdalar seizures)^[2].
Dosage:	40 mg/kg
Administration:	Intraperitoneal injection; single daily for 14 days.
Result:	Showed activity of anti-seizures. Significantly down-regulated GABA transporters GAT-1 in the hippocampus.

Animal Model:	Adult male Sprague-Dawley rats (100-120 g; cardiac hypertrophy model)^[3].
Dosage:	14, 28, 56 mg/kg (dissolved in 1% DMSO)
Administration:	Intraperitoneal injection; single daily for 6 weeks.
Result:	Significantly attenuated cardiac hypertrophy and fibrosis. Increased LV ejection fraction (EF), fractional shortening (FS) and E/A ratio. Markedly increased the expression of Hrd1 in the hearts of AAC rats.

storage

Store at -20°C

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