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Name Thiamine hydrochloride
CAS 67-03-8
EINECS(EC#) 200-641-8
Molecular Formula C12H18Cl2N4OS
MDL Number MFCD00012780
Molecular Weight 337.27
MOL File 67-03-8.mol

Chemical Properties

Appearance White crystalline powder
Melting point  250 °C (dec.)(lit.)
mp  250 °C (dec.)(lit.)
density  1.3766 (rough estimate)
refractive index  1.6000 (estimate)
FEMA  3322
Fp  9°C
storage temp.  2-8°C
solubility  H2O: 0.1 g/mL at 20 °C, clear, colorless
form  Crystalline Powder
pka pKa 4.8 (Uncertain);9.0 (Uncertain)
color  White to almost white
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, strong reducing agents.
PH 2.7-3.3
Water Solubility  1 g/mL
Sensitive  Light Sensitive & Hygroscopic
JECFA Number 1030
Merck  14,9295
BRN  3851771
CAS DataBase Reference 67-03-8(CAS DataBase Reference)
EPA Substance Registry System 67-03-8(EPA Substance)

Safety Data

Hazard Codes  Xi
Risk Statements 

R36/37/38:Irritating to eyes, respiratory system and skin .

Safety Statements 

S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .

RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1
RTECS  XI7350000
HS Code  29362200
Safety Profile

Poison by intravenous and intraperitoneal routes. Mildly toxic by ingestion. The vitamin is destroyed by alkalies and alkaline drugs such as phenobarbital sodium and by oxidzing and reducing agents. When heated to decomposition it emits very toxic fumes of HCl, Cl-, SOx, and NOx.


LD50 in mice (mg/kg): 89.2 i.v.; 8224 orally (Winter)

Hazard Information

Material Safety Data Sheet(MSDS)

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