64917-82-4

Schisantherin D is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera. Schisantherin D shows anti-HIV replication activities with an EC50 of 0.5 μg/mL. Schisantherin D inhibits endothelin receptor B (ETBR) and has hepatoprotective effects[1][2].

[1] D F Chen, et al. Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior. J Nat Prod. 1996 Nov;59(11):1066-8. DOI:10.1021/np9601667
[2] Jin-Biao Xu, et al. Lignans from Schisandra chinensis ameliorate alcohol and CCl 4-induced long-term liver injury and reduce hepatocellular degeneration via blocking ETBR. J Ethnopharmacol. 2020 Aug 10;258:112813. DOI:10.1016/j.jep.2020.112813