61301-33-5

Schisandrin C is a lignan originally isolated from Schizandrae that has diverse biological activities. It decreases viability of U937 cells in a concentration-dependent manner and induces cell cycle arrest at the G₁ phase when used at a concentration of 100 μM. Schisandrin C (5-20 μM) decreases hydrogen peroxide-induced cell death and production of reactive oxygen species (ROS) in C2C12 skeletal muscle cells. It also decreases levels of matrix metalloproteinase-2 (MMP-2), MMP-9, COX-2, VCAM-1, IL-1β, and TNF-α in hydrogen peroxide-stimulated C2C12 cells. Schisandrin C decreases lipoteichoic acid-induced production of nitric oxide (NO), prostaglandin E₂ (PGE₂; Item No. 14010), TNF-α, IL-1β, and IL-6 in mouse primary microglia. In vivo, schisandrin C (200 mg/kg) decreases serum alanine amino transferase (ALT) and aspartate amino transferase (AST) activity, increases hepatic mitochondrial and total glutathione (GSH) levels, and reduces liver injury in a mouse model of acetaminophen-induced liver injury partially via inhibition of the cytochrome P450 (CYP) isoforms CYP2E1, CYP1A2, and CYP3A11.

Colorless crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Schisandra chinensis.

Schisandrin C potently inhibits proprotein convertase subtillsin-kexin type 9 (PCSK9) mRNA expression. Also, it displays strong protective effects in SH-SY5Y cells against serum and glucose deprivation (SGD) injury.

[1] LI X Y. Bioactivity of neolignans from fructus Schizandrae.[J]. Memorias do Instituto Oswaldo Cruz, 1991, 86 Suppl 2: 31-37. DOI: 10.1590/s0074-02761991000600010
[2] CHEOL PARK. Induction of G1 arrest and apoptosis by schisandrin C isolated from Schizandra chinensis Baill in human leukemia U937 cells.[J]. International journal of molecular medicine, 2009, 24 4: 495-502. DOI: 10.3892/ijmm_00000258
[3] JEONG-SEOK KIM  Ho K Y. Schisandrin C enhances mitochondrial biogenesis and autophagy in C2C12 skeletal muscle cells: potential involvement of anti-oxidative mechanisms.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 2018, 391 2: 197-206. DOI: 10.1007/s00210-017-1449-1
[4] SUN YOUNG PARK . Schizandrin C exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microglia[J]. International immunopharmacology, 2013, 17 2: Pages 415-426. DOI: 10.1016/j.intimp.2013.06.032
[5] YIMING JIANG . Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation[J]. Chemico-Biological Interactions, 2015, 231: Pages 83-89. DOI: 10.1016/j.cbi.2015.02.022