58546-54-6

Schisandrol B is a lignan originally isolated from S. chinensis that has hepatoprotective activity. It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells. It also protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice and decreases mortality in a mouse model of cholestasis when administered at a dose of 100 mg/kg twice per day. It also promotes liver regeneration following partial hepatectomy and protects against hepatotoxicity induced by acetaminophen (Item No. 10024).

White powder

Schizandrol B exhibits potent protective effects of on ET-1-induced dysfunctional human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs). Anti-cholestasis effect.

CYP2; CYP3A

[1] H. TAGUCHI Y I. The Constituents of Schizandra chinensis BAILL. I. The Structures of Gomisin A, B and C[J]. Chemical & pharmaceutical bulletin, 1975, 114 1: 3296-3298. DOI: 10.1248/cpb.23.3296
[2] HANG ZENG. Schisandrol B protects against cholestatic liver injury through pregnane X receptors[J]. British Journal of Pharmacology, 2017, 174 8: 672-688. DOI: 10.1111/bph.13729
[3] XI LI . Schisandrol B promotes liver regeneration after partial hepatectomy in mice[J]. European journal of pharmacology, 2018, 818: Pages 96-102. DOI: 10.1016/j.ejphar.2017.10.044
[4] YI-MING JIANG. Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway[J]. Acta Pharmacologica Sinica, 2016, 37 3: 382-389. DOI: 10.1038/aps.2015.120