Supplier Related Products Identification Chemical Properties Safety Data Hazard Information
WebSite >  CAS DataBase List  > 7432-28-2

7432-28-2

Supplier Related Products Identification Chemical Properties Safety Data Hazard Information

Product Image

Identification

Name
Schisandrin
CAS
7432-28-2
Synonyms
12aR)-
schizandra
SCHIZANDROL
SCHIZANDRIN
SCHISANDRIN
Schisandrol
Schisadrol A
SCHISANDROL A
SCHIZANDROL A
Schizandrin std.
WUWEIZI ALCOHOL A
Schizandrin, >=98%
Schisandrin,Schizandrin
Schisandrol A 7432-28-2
Schisandrin (Schizandrol
Schisandrae Berry Extract
Schisandrin(Schizandrol A)
SCHISANDRIN (SCHISANDROL A)
hot selling Schisandra Berries P.E
DeoxyschizandrinSchisandra chinensis extract
1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-,(6S,7S
Dibenzo[a,c]cycloocten-6-ol, 5,6,7,8-tetrahydro-
Schizandrin, 98%, from Schisandra chinensis (Turcz.) Baill.
(+)-Schizandrin Schisandrin Schisandrine Wuweizi alcohol A Schizandrin
dibenzo(a,c)cycloocten-6-ol,5,6,7,8-tetrahydro-6,7-dimethyl-1,23,10,11,12-hex
5,6,7,8-Tetrahydro-6,7-dimethyl-1,2 3,10,11,12-hexamethoxydibenzo[a,c]cycloocten-6-ol
5,6,7,8-Tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyldibenzo[a,c]cycloocten-6-ol
chisandrin 5,6,7,8-Tetrahydro-6,7-dimethyl-1,2 3,10,11,12-hexamethoxydibenzo[a,c]cycloocten-6-ol
Dibenzo[a,c]cycloocten-6-ol, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, (6S,7S,12aR)-
Molecular Formula
C24H32O7
MDL Number
MFCD00238680
Molecular Weight
432.51
MOL File
7432-28-2.mol

Chemical Properties

Melting point 
128.5°C
Boiling point 
466.17°C (rough estimate)
density 
1.1480 (rough estimate)
refractive index 
1.5800 (estimate)
storage temp. 
room temp
solubility 
DMSO: ≥13mg/mL
form 
powder
pka
14.58±0.40(Predicted)
color 
white to beige
optical activity
[α]/D 75 to 95°, c = 1 in methanol
InChIKey
YEFOAORQXAOVJQ-UHFFFAOYSA-N

Safety Data

Hazard Codes 
Xn,N
Risk Statements 
22-50/53
Safety Statements 
60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
HS Code 
29093090

Hazard Information

Description
Schizandrin is a dibenzocyclooctadiene lignan and a major component of S. chinensis and has diverse biological activities. It induces cell cycle arrest at the G0/G1 phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells when used at a concentration of 100 μM. Schizandrin (10 and 100 μM) prevents glutamate-induced cytotoxicity, inhibits production of nitric oxide (NO) and reactive oxygen species (ROS), and preserves the mitochondrial membrane potential in isolated rat cortical cells. It reduces apoptosis induced by cisplatin (Item No. 13119) in HK-2 human kidney cells. In vivo, schizandrin (1 and 10 mg/kg, p.o.) reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats. It enhances oxotremorine-induced tremors in mice. Schizandrin (10 mg/kg) reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy.
Biochem/physiol Actions
Schizandrin is a natural product with several biological properties involved with antioxidant and anti-inflammatory activities. It reduces the formation of ROS, inhibits the mitochondrial pathway of the apoptotic process and oxidative stress. Schizandrin has been reported to have hepatoprotective, antitumor, antiviral, and antiamnesic effects, and has neuroprotective activity against glutamate induced neurotoxicity.
SupplierMore