Schizandrin is a dibenzocyclooctadiene lignan and a major component of
S. chinensis and has diverse biological activities.
1,2,3,4,5 It induces cell cycle arrest at the G
0/G
1 phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells when used at a concentration of 100 μM.
1 Schizandrin (10 and 100 μM) prevents glutamate-induced cytotoxicity, inhibits production of nitric oxide (NO) and reactive oxygen species (ROS), and preserves the mitochondrial membrane potential in isolated rat cortical cells.
2 It reduces apoptosis induced by cisplatin (Item No.
13119) in HK-2 human kidney cells.
3 In vivo, schizandrin (1 and 10 mg/kg, p.o.) reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats.
4 It enhances oxotremorine-induced tremors in mice. Schizandrin (10 mg/kg) reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy.
5