Description
3-amino-4-fluorophenol is a kind of organic chemistry intermediate commonly used as the intermediate for synthesizing compounds of liquid crystals, pharmaceutical compounds and agricultural chemical compounds used always.
Uses
3-Amino-4-fluorophenol is used to produce drugs with specific biological activities, including antibiotics and anti-inflammatory agents.
Synthesis
Add 450ml water in the 5L reaction flask, 708.5g (10.9mol) zinc powder, 303g (1.09mol) 2-bromo-4-fluoro-5-amino-benzene oxygen ethyl formate, mix, 45 ℃ drip the solution that 218g (5.45mol) sodium hydroxide and 1500ml water are made into down, insulated and stirred is warming up to 60 ℃ after 1 hour to be incubated 4 hours after reactions more complete, the cooling suction filtration, getting filtrate dropping 406g (3.33mol) 30% hydrochloric acid separates product, filtration obtains brown solid, use ethyl alcohol recrystallization, get yellow solid 118.5g (0.93mol) 3-amino-4-fluorophenol after the drying. A molar yield of 85% is 99.5% through gas chromatography determination purity.136 ℃/20mmHg of boiling point.
References
[1] Organic Process Research and Development, 2014, vol. 18, # 1, p. 122 - 134
[2] Patent: US2008/90856, 2008, A1. Location in patent: Page/Page column 38
[3] Patent: WO2010/51373, 2010, A1. Location in patent: Page/Page column 75-76
[4] Patent: WO2013/36232, 2013, A2. Location in patent: Paragraph 00253
[5] Patent: US2009/137595, 2009, A1
