612-16-8

Colorless to light yellow liqui

It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals.

Synthesis of 2-Methoxybenzyl Alcohol: Under an inert nitrogen (N₂) atmosphere, after dehydration and deoxygenation, 2-methoxybenzoic acid (76.2 mg, 0.5 mmol) was added to the reaction flask, followed by the addition of liquid borane (290 μL, 2 mmol). The reaction was carried out at room temperature for 12 hours. After completion, the mixture was removed from the glovebox, and trimethoxybenzene (84.23 mg, 0.5 mmol) was added as an internal standard. The mixture was dissolved in CDCl₃, stirred for 10 minutes, and then sampled for nuclear magnetic resonance (NMR) analysis. The yield was calculated to be 99%.

Tetrahedron Letters, 32, p. 5629, 1991 DOI: 10.1016/0040-4039(91)80103-D

Notclassified

[1] GIOVANNI PALMISANO . Unexpectedly ambivalent O2 role in the autocatalytic photooxidation of 2-methoxybenzyl alcohol in water[J]. Journal of Molecular Catalysis A: Chemical, 2015, 403: Pages 37-42. DOI:10.1016/j.molcata.2015.03.021.
[2] P. ROVERO. Solid support-dependent alkylation of tryptophan residues in SPPS using a 2-methoxybenzyl alcohol-based linker[J]. Letters in peptide science : LIPS, 1994, 38 1: 149-155. DOI:10.1007/BF00128533.