598-02-7

Name	DIETHYL PHOSPHATE
CAS	598-02-7
EINECS(EC#)	209-912-5
Molecular Formula	C4H11O4P
MDL Number	MFCD00039889
Molecular Weight	154.1
MOL File	598-02-7.mol

Synonyms

IETHYLPHOSPHATE di-ethylphosphat DIETHYL PHOSPHATE ETHYLACIDPHOSPHATE O,O-DIETHYLPHOSPHATE diethylacidphosphate diethylphosphoricacid Diethyl phosphate,98% Diethyl acid phosphate Diethyl phosphoric acid Phosphoric acid diethyl DIETHYL HYDROGEN PHOSPHATE Phosphoricacid,diethylester o,o-diethylhydrogenphosphate Ethyl phosphate, (ETO)2(HO)PO Diethyl phosphate, tech., 75% DIETHYL PHOSPHATE, 100MG, NEAT Diethyl phosphate (mono- & di-) Diethyl hydrogen phosphate solution Phosphoric acid hydrogen diethyl ester Diethyl phosphate,75%,tech., balance phosphoric acid Diethyl phosphate, 75%, balance phosphoric acid, tech. Diethyl phosphate, tech., balance phosphoric acid, 75%

Chemical Properties

Appearance	clear colorless to light yellow-orange liquid
Melting point	6 °C
Boiling point	203 °C
density	1.29
refractive index	1.4170
Fp	91 °C
storage temp.	?20°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Liquid
pka	1.42±0.50(Predicted)
color	Clear colorless to light yellow-orange
Stability:	Moisture Sensitive
EPA Substance Registry System	Phosphoric acid, diethyl ester (598-02-7)

Safety Data

Hazard Codes	Xi,T,F
Risk Statements	36/37/38-39/23/24/25-23/24/25-11 less more
Safety Statements	37/39-26-36-45-36/37-16-7 less more
RTECS	TC0665000
HS Code	29199000

Raw materials And Preparation Products

Hazard Information

Chemical Properties

clear colorless to light yellow-orange liquid

Definition

ChEBI: A dialkyl phosphate having ethyl as the alkyl group.

Uses

Phosphoric acid diethyl ester is an organophosphate that is usually found in pesticides and is known to induce changes in male hormone profile by decreasing serum testosterone and inhibin B levels. Phosphoric acid diethyl ester is also known to negatively affect the health of women and newborns living in agricultural communities.

Synthesis Reference(s)

The Journal of Organic Chemistry, 28, p. 2089, 1963 DOI: 10.1021/jo01043a035
Tetrahedron Letters, 29, p. 619, 1988 DOI: 10.1016/S0040-4039(00)80165-3

in vivo

Diethyl phosphate (oral gavage; 0.08-0.8 mg/kg; 24 weeks) can lead to the disturbance of endocrine hormones and related metabolic indexes in rats^[1].
Diethyl phosphate (oral gavage; 0.08-0.13 mg/kg; 20 weeks) affects the intestinal microbiota, serum hormones and pro-inflammatory cytokines^[2].

Animal Model:	Adult male Wistar rats aged 7-8 weeks old (344.4 ± 21.0 g)^[1]
Dosage:	0.08 or 0.8 mg/kg
Administration:	Oral gavage (i.g.); 24 weeks
Result:	Did not affect the body weight of rats and food intake. Significantly decreased serum levels of TC, TG and LDL-C in rats. Resulted in a decrease in sperm concentration, while the sperm abnormality rate increased, did not affect the sperm morphology in rats. Increased the serum levels of FSH and estradiol, while the serum levels of LH and testosterone decreased. Could cause thyroid-related hormone disorders in the serum of rats, causing symptoms of hyperthyroidism in rats, and could also lead to abnormal expression of thyroid hormone-related genes in the rat liver.

Animal Model:	Male Wistar rats aged 7 weeks old^[2]
Dosage:	0.08 or 0.13 mg/kg
Administration:	Oral gavage (i.g.); 20 weeks
Result:	Significantly enriched opportunistic pathogens, including Paraprevotella, Parabacteroides, Alloprevotella, and Helicobacter, leading to a decrease in IL-6. Enriched the butyrate-producing genera, Alloprevotella and Intestinimonas, leading to an increase in estradiol and a resulting decrease in total triglycerides (TGs) and low-density lipoprotein cholesterol (LDL-C) in high dose group. Induced increases in peptide tyrosine-tyrosine (PYY) and ghrelin.

Spectrum Detail

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