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78-30-8

Name TRI-O-CRESYL PHOSPHATE
CAS 78-30-8
EINECS(EC#) 201-103-5
Molecular Formula C21H21O4P
MDL Number MFCD00041906
Molecular Weight 368.36
MOL File 78-30-8.mol

Chemical Properties

Appearance Tricresyl phosphates are available as the o-isomer (TOCP), the m-isomer (TMCP), and p-isomer (TPCP). The ortho-isomer is the most toxic of the three; the meta-and para-isomers are relatively inactive. The commercial product may contain the ortho-isomer as a contaminant unless special precautions are taken during manufacture. Pure tri-para-cresyl phosphate is a solid, and ortho-and meta-are liquids (see below). The tri-o-cresyl phosphate will be discussed here as the specific example of these compounds because it is the most toxic of the tricresyl phosphates and specifically regulated by OSHA. TOCP is a colorless to pale yellow, odorless liquid or solid (below 52/F/11℃).
Melting point  -25 °C
Boiling point  410 °C
density  1.2
vapor pressure  0.195 at 50 °C (Carré and Bertrans, 1998)
refractive index  1.558-1.561
Fp  225 °C
storage temp.  Inert atmosphere,2-8°C
solubility  sparingly soluble in water; soluble in acetic acid; freely soluble in alcohol, benzene, ether; very soluble in carbon tetrachloride, toluene.
maximum allowable concentration: 0.1 mg/m3 (TLV-TWA) (ACGIH 1986)
form  Viscous Liquid
color  Clear colorless to yellow
Merck  9764
Exposure limits TLV-TWA skin 0.1 mg/m3 (ACGIH and OSHA); IDLH 40 mg/m3 (NIOSH).
CAS DataBase Reference 78-30-8(CAS DataBase Reference)
EPA Substance Registry System Tri-o-cresyl phosphate (78-30-8)

Safety Data

Hazard Codes  N-T,N,T
Risk Statements 
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
Safety Statements 
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S20/21:When using, do not eat, drink or smoke .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
RIDADR  3082
RTECS  TD0350000
HazardClass  6.1(a)
PackingGroup  II
HS Code  29199000
Safety Profile
Poison by subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Most of the cases of tri-o-cresyl phosphate poisoning have followed its ingestion. In 1930, some 15,000 persons were affected in the United States, and of these, 10 died. The responsible material was found to be an alcoholic drink known as Jamaica ginger, or "jake." This beverage had been adulterated with about 2% of tri-o-cresyl phosphate. The affected persons developed a polyneuritis, which progressed, in many cases, with degeneration of the peripheral motor nerves, the anterior horn cells, and the pyramidal tracts. Sensory changes were absent. Since 1930 there have been several other outbreaks of poisoning following ingestion of the material. Tri-ocresyl phosphate is more toxic than the mform, and much more so than tri-p-cresyl phosphate or triphenyl phosphate. Experimental reproductive effects. flame. Can react with oxidizing materials. To fight fire, use CO2, dry chemical. When heated to decomposition it emits highly toxic fumes of POx. See also PHOSPHATES. Combustible when exposed to heat or
Hazardous Substances Data 78-30-8(Hazardous Substances Data)
Toxicity
Acute oral LD50 for rats 160 mg/kg (quoted, RTECS, 1985).
IDLA 40 mg/m3

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