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78-30-8

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Identification

Name
TRI-O-CRESYL PHOSPHATE
CAS
78-30-8
Synonyms
O-TOLYL PHOSPHATE
PHOSPHORIC ACID TRI-O-CRESYL ESTER
PHOSPHORIC ACID TRI-O-TOLYL ESTER
TRI-O-CRESYL PHOSPHATE
TRI-O-TOLYL PHOSPHATE
NCLC61041
o-Cresyl phosphate
o-cresylphosphate
o-Trikesylphosphate
o-trikresylphosphate
o-Trioyl phosphate
Phosflex 179C
phosflex179c
phosphatedetri-o-cresyle
Phosphoric acid, tri-2-methylphenyl ester
Phosphoric acid, tri-o-cresyl ether
Phosphoric acid, tris(2-methylphenyl) ester
phosphoricacid,tri(2-tolyl)ester
Phosphoricacid,tris(2-methylphenyl)ester
phosphoricacidtri(2-methylphenyl)ester
EINECS(EC#)
201-103-5
Molecular Formula
C21H21O4P
MDL Number
MFCD00041906
Molecular Weight
368.36
MOL File
78-30-8.mol

Chemical Properties

Appearance
clear colourless to yellow viscous liquid
Appearance
Tricresyl phosphates are available as the o-isomer (TOCP), the m-isomer (TMCP), and p-isomer (TPCP). The ortho-isomer is the most toxic of the three; the meta-and para-isomers are relatively inactive. The commercial product may contain the ortho-isomer as a contaminant unless special precautions are taken during manufacture. Pure tri-para-cresyl phosphate is a solid, and ortho-and meta-are liquids (see below). The tri-o-cresyl phosphate will be discussed here as the specific example of these compounds because it is the most toxic of the tricresyl phosphates and specifically regulated by OSHA. TOCP is a colorless to pale yellow, odorless liquid or solid (below 52/F/11℃).
mp 
-25 °C
bp 
410 °C
density 
1.2
refractive index 
1.558-1.561
Fp 
225 °C
Merck 
9764
CAS DataBase Reference
78-30-8(CAS DataBase Reference)

Safety Data

Hazard Codes 
N-T,N,T
Risk Statements 
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
Safety Statements 
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S20/21:When using, do not eat, drink or smoke .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
RIDADR 
3082
RTECS 
TD0350000
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
29199000
Safety Profile
Poison by subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Most of the cases of tri-o-cresyl phosphate poisoning have followed its ingestion. In 1930, some 15,000 persons were affected in the United States, and of these, 10 died. The responsible material was found to be an alcoholic drink known as Jamaica ginger, or "jake." This beverage had been adulterated with about 2% of tri-o-cresyl phosphate. The affected persons developed a polyneuritis, which progressed, in many cases, with degeneration of the peripheral motor nerves, the anterior horn cells, and the pyramidal tracts. Sensory changes were absent. Since 1930 there have been several other outbreaks of poisoning following ingestion of the material. Tri-ocresyl phosphate is more toxic than the mform, and much more so than tri-p-cresyl phosphate or triphenyl phosphate. Experimental reproductive effects. flame. Can react with oxidizing materials. To fight fire, use CO2, dry chemical. When heated to decomposition it emits highly toxic fumes of POx. See also PHOSPHATES. Combustible when exposed to heat or

Raw materials And Preparation Products

Raw materials
o-Cresol-->Cresol-->Tritolyl phosphate

Hazard Information

Potential Exposure
Tricresyl phosphate is used as an additive in hydraulic fluids; as a plasticizer; pigment dispersant; flame retardant; as a plasticizer for chlorinated rubber; vinyl plastics; polystyrene, polyacrylic, and polymethacrylic esters; as an adjuvant in milling of pigment pastes; as a solvent and as a binder in nitrocellulose and various natural resins, and as an additive to synthetic lubricants and gasoline. It is also used in the recovery of phenol in coke-oven wastewaters.
First aid
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Speed in removing material from skin is of extreme importance. Shampoo hair promptly if contaminated. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Effects may be delayed. Medical observation is recommended.
Shipping
UN2574 Tricresyl phosphate with >3% ortho (o-) isomer, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Contact with magnesium may cause explosion. Organophosphates, such as tricresyl phosphate, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrideds and active metals. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

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