59528-27-7

4-Iodobenzylamine hydrochloride is used to prepare cyclic amide by reacting with methyl 4-bromomethyl-3-methoxycarbonylcinnamate in the presence of triethylamine. It is also used in pharmaceuticals, agrochemicals and dye industries.

To a suspension of 4-iodobenzamide (11 g, 45 mmol) in THF (50 mL) was added BH3-THF (1M, 22.5 mL, ). 22.5 mmol). The resulting solution was heated to reflux overnight. The reaction was cooled in an ice bath and MeOH-HCl (60 mL) was added slowly and dropwi