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• Synthesis methods

  Industrial parabromoaniline is as raw material, by diazotization, iodo-synthesis of bromo iodobenzene. Preferred synthesis conditions: firstly 0.02mol parabromoaniline is dissolved in a mass fraction of 20% sulfuric acid medium, then reacts with 0.021molNaNO2 to generate bromophenyl diazonium sulfate at-10℃, and then chloroform and 0.021molKI is added into solution to process iodination reaction, after simple treatment bromo-iodobenzene crude product (which the bromo-iodobenzene HPLC purity 98.4%) is obtained, total yield after purification is 80%, increases by 15% than before improved. The product processes structural characterization by IR and 1HNMR. The improved method can greatly improve the purity of the crude product, this avoids the trouble of going through the column, this method is safe and easy to operate, easy to control the process, cost is lower, it is more suitable for the preparation of 1-Bromo-4-iodobenzene.
  Unit: Heilongjiang University of Chemistry and Materials Science
  Author: Guo Jing Bai Xuefeng Lvhong Fei;

• Uses

  1. 1-Bromo-4-iodobenzene is used for organic synthesis.
  2. Used as substrate for copper-free Sonogashira coupling reaction in aqueous acetone.
  3. For the synthesis of β,β-dibromostyrene.;

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