Hazard
Toxic by ingestion. Questionable carcino-
gen.
Potential Exposure
This material is used as a reagent for ketones and aldehydes with which it affords crystalline compounds having characteristic freezing/melting points. Also used in isolation of hormones and certain fractions from essential oils.
First aid
Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. May ignite combustible materials (wood, oil, paper).
Chemical Properties
Semicarbazide hydrochloride is a white crystalline solid.
Chemical Properties
White Solid
Uses
A metabolite of Nitrofuran.
Uses
Inhibitor of enzyme. Hypotensive
Definition
ChEBI: Semicarbazide hydrochloride is an organic molecular entity.
Health Hazard
Semicarbazide hydrochloride is a chemical reagent, and an indicator for its metabolic parent nitrofurazone, a veterinary drug that has been banned for use in livestock production in the European Union and the U.S. amongst other jurisdictions.
After Semicarbazide hydrochloride ingestion, experimental animals have developed tremors, ataxia, equilibrium difficulties, and convulsions. Its proposed mechanism of action is by binding to cytosine residues in RNA, to deoxycytosine residues in DNA and to cytosine and deoxycytosine nucleosides.
Semicarbazide hydrochloride has an oral LD50 of 225mg/kg in mice and 123 mg/kg in the rat. Some studies suggest that Semicarbazide hydrochloride is a mutagen, an animal carcinogen and a teratogen.
Due to the lack of data in humans and overall limited evidence of carcinogenicity in animals, semicarbazide hydrochloride was classified as an IARC Group 3 agent: not classifiable as to its carcinogenicity to humans. Due to its equivocal carcinogenic and mutagenic properties, when handling Semicarbazide hydrochloride and animals treated with Semicarbazide hydrochloride, it is imperative to take caution and adhere to the following guidelines to minimize exposure and the effects of exposure during normal and emergency situations.
Flammability and Explosibility
Notclassified
Purification Methods
Crystallise the salt from aqueous 75% EtOH and dry it under vacuum over CaSO4. Alternatively crystallise it from a mixture of 3.6 mole % MeOH and 6.4 mole % of water. [Kovach et al. J Am Chem Soc 107 7360 1985.] IR: 700, 3500 cm-1 [Ingersoll et al. Org Synth Coll Vol I 485 1941, Davison & Christie J Chem Soc 3389 1955, Thiele & Stange Chem Ber 27 33 1894, pK: Bartlett J Am Chem Soc 54 2853 1923]. The free base crystallises as prisms from absolute EtOH, m 96o. [Curtius & Heidenreich Chem Ber 27 55 1894, Beilstein 3 IV 177.] TOXIC ORALLY, possible CARCINOGEN and TERATOGEN.
