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1-Hydroxyrutaecarpine (compound 1a) is a hydroxy-derivative of rutaecarpine. 1-Hydroxyrutaecarpine shows cytotoxicities with ED50s of 3.72, 7.44 μg/mL for P-388 and HT-29 cells, respectively. 1-Hydroxyrutaecarpine shows antiplatelet activity[1][2][3].

[1] Bruno Danieli; et al. 1-Hydroxyrutaecarpine from Euxylophora para?nsis. Phytochemistry, 1974 , 13(8), 1603–1606.
[2] Chen JJ, et al. New indolopyridoquinazoline, benzo[c]phenanthridines and cytotoxic constituents from Zanthoxylum integrifoliolum. Planta Med. 2005 May;71(5):470-5. DOI:10.1055/s-2005-864144
[3] Sheen WS, et al. Indolopyridoquinazoline alkaloids with antiplatelet aggregation activity from Zanthoxylum integrifoliolum. Planta Med. 1996 Apr;62(2):175-6. DOI:10.1055/s-2006-957846