53-60-1

Name	Promazine hydrochloride
CAS	53-60-1
EINECS(EC#)	200-179-7
Molecular Formula	C17H21ClN2S
MDL Number	MFCD00058535
Molecular Weight	320.88
MOL File	53-60-1.mol

Synonyms

10-[3-(DIMETHYLAMINO)PROPYL]-PHENOTHIAZINE HYDROCHLORIDE n,n-dimethyl-10h-phenothiazine-10-propanamine hydrochloride PROMAZINE HCL PROMAZINE HYDROCHLORIDE 10-(3-(Dimethylamino)propyl)phenothiazine monohydrochloride 10-(3-(dimethylamino)propyl)phenothiazinemonohydrochloride 10-(3-(dimethylamino)propyl)-phenothiazinhydrochloride 10-(3-(dimethylamino)propyl)-phenothiazinmonohydrochloride 10-(gamma-Dimethylamino-n-propyl)phenothiazine hydrochloride 10-(gamma-dimethylamino-n-propyl)phenothiazinehydrochloride 10H-Phenothiazine-10-propanamine, N,N-dimethyl-, monohydrochloride chlorowodorekpromazyny component of Ketaset plus (veterinary) Esparinal Liranol Megaphen N-(3-(Dimethylamino)propyl)phenothiazine hydrochloride n,n-dimethyl-10h-phenothiazine-10-propanaminmonohydrochloride Phenothiazine, 10-(3-(dimethylamino)propyl)-, hydrochloride Phenothiazine, 10-(3-(dimethylamino)propyl)-, monohydrochloride

Chemical Properties

Definition	Isomeric with promethazine hydrochloride.
Melting point	174-176?C
density	1.1435 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
form	neat
color	White
BRN	3753230
CAS DataBase Reference	53-60-1(CAS DataBase Reference)
NIST Chemistry Reference	N,N-dimethyl-10H-phenothiazine-1-propanamine hydrochloride(53-60-1)
EPA Substance Registry System	53-60-1(EPA Substance)

Safety Data

Hazard Codes	Xn
Risk Statements	R22:Harmful if swallowed. R43:May cause sensitization by skin contact. less more
Safety Statements	S36:Wear suitable protective clothing . less more
WGK Germany	3
RTECS	SO8575000
HS Code	2934302300
Safety Profile	Poison by ingestion, subcutaneous, intravenous, intraperitoneal, and intramuscular routes. Human systemic effects by ingestion: general anesthesia, tremors, antipsychotic effects. An addltive permitted in food for human consumption; also permitted in the feed and drinhng water of animals and/or for the treatment of food-producing animals. When heated to decomposition it emits toxic fumes of NOx, SOx, and HCl less more

Hazard Information

Chemical Properties

White Solid

Uses

Antipsychotic. Tranquilizer.

Brand name

Sparine (Baxter Healthcare); Sparine (Wyeth).

General Description

Promazine hydrochloride (PMZ) belongs to the phenothiazine drug family. Promazine is a D2 dopamine receptor antagonist and has antipsychotic and anticholinergic functionality. It is used for pain management and is also used for treating hypersensitivity reactions.

Biochem/physiol Actions

D2 dopamine receptor antagonist; phenothiazine antipsychotic.

Clinical Use

Antipsychotic for agitation and restlessness

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: increased risk of convulsions with tramadol; enhanced hypotensive and sedative effects with opioids; increased risk of ventricular arrhythmias with methadone.
Anti-arrhythmics increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval, e.g. procainamide, disopyramide, dronedarone and amiodarone - avoid with amiodarone and dronedarone.
Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid.
Antidepressants: increase concentrations and additive antimuscarinic effects, notably with tricyclics; increased risk of ventricular arrhythmias with citalopram and escitalopram - avoid; increased risk of convulsions with vortioxetine.
Antiepileptics: antagonised (convulsive threshold lowered).
Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol.
Antipsychotics: increased risk of ventricular arrhythmias with droperidol and pimozide - avoid; increased risk of ventricular arrhythmias with risperidone.
Antivirals: concentration possibly increased with ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid.
Anxiolytics and hypnotics: increased sedative effects.
Atomoxetine: increased risk of ventricular arrhythmias.
Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol.
Cytotoxics: increased risk of ventricular arrhythmias with arsenic trioxide.
Desferrioxamine: avoid concomitant use.
Diuretics: enhanced hypotensive effect.
Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity.
Pentamidine: increased risk of ventricular arrhythmias.
Anti-arrhythmics: increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval - avoid with amiodarone, disopyramide and dronedarone.
Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid.
Antidepressants: increased level of tricyclics (possibly increased risk of ventricular arrhythmias and antimuscarinic side effects); increased risk of ventricular arrhythmias with citalopram and escitalopram - avoid; increased risk of convulsions with vortioxetine.
Anticonvulsant: antagonises anticonvulsant effect.
Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol.
Antipsychotics: increased risk of ventricular arrhythmias with droperidol and pimozide - avoid; increased risk of ventricular arrhythmias with risperidone.
Antivirals: concentration possibly increased with ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid.
Anxiolytics and hypnotics: increased sedative effects.
Atomoxetine: increased risk of ventricular arrhythmias.
Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol.
Cytotoxics: increased risk of ventricular arrhythmias with arsenic trioxide.
Diuretics: enhanced hypotensive effect.
Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity.
Pentamidine: increased risk of ventricular arrhythmias.

Metabolism

Promazine undergoes considerable first-pass metabolism in the gut wall. It is also extensively metabolised in the liver and is excreted in the urine and faeces in the form of numerous active and inactive metabolites.

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