Identification Chemical Properties Safety Data Raw materials And Preparation Products Hazard Information Material Safety Data Sheet(MSDS) Spectrum Detail Well-known Reagent Company Product Information Supplier Related Products

51803-78-2

Name Nimesulide
CAS 51803-78-2
EINECS(EC#) 257-431-4
Molecular Formula C13H12N2O5S
MDL Number MFCD00079470
Molecular Weight 308.31
MOL File 51803-78-2.mol

Chemical Properties

Appearance Yellow Needle-Like Crystals
Melting point  140-146°C
Boiling point  442.0±55.0 °C(Predicted)
density  1.451±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  Practically insoluble in water, freely soluble in acetone, slightly soluble in anhydrous ethanol.
form  neat
pka pKa 6.56± 0.03(H2O,t =25,I=0.02)(Approximate)
color  Light orange to Yellow to Green
Stability: Stable. Incompatible with strong oxidizing agents.
Water Solubility  Soluble in water (<50 &#181;g/ml), 1:10 DMSO:PBS (pH 7.2) (<200 &#181;g/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.
Usage Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-alpha production
λmax 391nm(H2O)(lit.)
Merck  14,6548
InChIKey HYWYRSMBCFDLJT-UHFFFAOYSA-N
CAS DataBase Reference 51803-78-2(CAS DataBase Reference)
EPA Substance Registry System Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)- (51803-78-2)

Safety Data

Hazard Codes  Xn,Xi
Risk Statements 
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements 
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  PB0970000
HS Code  2935.90.9500
HazardClass  6.1
PackingGroup  III
Toxicity
LD50 orally in rats: 324 mg/kg (Swingle, Moore)

Raw materials And Preparation Products

Hazard Information

Material Safety Data Sheet(MSDS)

Spectrum Detail

Well-known Reagent Company Product Information

Supplier