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498-00-0

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Identification

Name
4-Hydroxy-3-methoxybenzyl alcohol
CAS
498-00-0
Synonyms
4-HYDROXY-3-METHOXYBENZYL ALCOHOL
4-HYDROXYMETHYL-2-METHOXY-PHENOL
A 4-DIHYDROXY-3-METHOXYTOLUENE
FEMA 3737
RARECHEM AL BD 0101
VANILLYL ALCOHOL
4-hydroxy-3-methoxy-benzenemethano
4-hydroxy-3-methoxybenzyl
4-hydroxy-3-methoxybenzylalcohol(vanillicalcohol)
Benzenemethanol, 4-hydroxy-3-methoxy-
vanillol
VANILLYL ALCOHOL MI
VANILLYL ALCOHOL 98+%
Vanillyl alcohol (4-Hydroxy-3-methoxybenzyl alcohol)
Vanillyl
CITRONELLOL, D-(SG)
HOMOVANILLICALCOHOL
4-HYDROXY-3-METHOXYBENZENEMETHANOL
4-HYDROXY-3-METHOXYBENZYL ALCOHOL, 98+%
4-HYDROXY-3-METHOXYBENZYL ALCOHOL (VANILLYL ALCOHOL)
EINECS(EC#)
207-852-4
Molecular Formula
C8H10O3
MDL Number
MFCD00004659
Molecular Weight
154.16
MOL File
498-00-0.mol

Chemical Properties

Appearance
crystalline white to off-white powder
mp 
110-117 °C(lit.)

FEMA 
3737
Stability:
Stable. Incompatible with strong oxidizing agents, strong acids.
BRN 
1910044
CAS DataBase Reference
498-00-0(CAS DataBase Reference)
NIST Chemistry Reference
4-Hydroxy-3-methoxybenzyl alcohol(498-00-0)

Safety Data

Hazard Codes 
Xi
Risk Statements 
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
WGK Germany 
3

Hazard Note 
Irritant
HS Code 
29095090

Material Safety Data Sheet(MSDS)

Questions and Answers (Q&A)

Description
4-hydroxy-3-methoxybenzyl alcohol (also known as vanillyl alcohol) is often used as a deodorant component that is active in preventing the formation of body odor. It can also be used as a flavoring agent. Recent studies have also demonstrated that it has certain pharmacological effects. For example, it has been confirmed that it has certain neuro-protective effects through suppressing the oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells, making it a potential candidate for the treatment of neurodegenerative diseases such as Parkinson’s disease.
References
Brune, I, et al. "Under the influence of the active deodorant ingredient 4-hydroxy-3-methoxybenzyl alcohol, the skin bacterium Corynebacterium jeikeium moderately responds with differential gene expression." Journal of Biotechnology 127.1(2006):21-33.
Hsu, Lun Chung, Z. H. Wen, and K. Y. Lee. "Use of vanillyl alcohol for the treatment of Parkinson's disease." (2009).
Kim, I. S., D. K. Choi, and H. J. Jung. "Neuroprotective effects of vanillyl alcohol in Gastrodia elata Blume through suppression of oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells." Molecules 16.7(2011):5349.

Spectrum Detail

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