ChemicalBook CAS DataBase List 4637-24-5

4637-24-5

Name	N,N-Dimethylformamide dimethyl acetal
CAS	4637-24-5
EINECS(EC#)	225-063-3
Molecular Formula	C5H13NO2
MDL Number	MFCD00008482
Molecular Weight	119.16
MOL File	4637-24-5.mol

Chemical Properties

Appearance	clear colourless liquid
Melting point	-85°C
Boiling point	102-103 °C/720 mmHg (lit.)
density	0.897 g/mL at 25 °C(lit.)
vapor pressure	34.5hPa at 20℃
refractive index	n20/D 1.396(lit.)
Fp	45 °F
storage temp.	Flammables area
solubility	Miscible with most organic solvents.
form	Solid
pka	5.00±0.50(Predicted)
color	White to off-white
PH	7 (H2O)
explosive limit	1.3-17.7%(V)
Water Solubility	hydrolysis
Sensitive	Moisture Sensitive
Detection Methods	GC,NMR
BRN	506020
Exposure limits	ACGIH: TWA 200 ppm; STEL 250 ppm (Skin) OSHA: TWA 200 ppm(260 mg/m3) NIOSH: IDLH 6000 ppm; TWA 200 ppm(260 mg/m3); STEL 250 ppm(325 mg/m3)
LogP	0.750 (est)
CAS DataBase Reference	4637-24-5(CAS DataBase Reference)
NIST Chemistry Reference	Methanamine, 1,1-dimethoxy-N,N-dimethyl-(4637-24-5)
Storage Precautions	Moisture sensitive
EPA Substance Registry System	4637-24-5(EPA Substance)

Safety Data

Hazard Codes	F,Xn,Xi
Risk Statements	R11:Highly Flammable. R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin . R36/38:Irritating to eyes and skin . R20:Harmful by inhalation. R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R10:Flammable. less more
Safety Statements	S16:Keep away from sources of ignition-No smoking . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37:Wear suitable protective clothing and gloves . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S33:Take precautionary measures against static discharges . S29:Do not empty into drains . S7/9:Keep container tightly closed and in a well-ventilated place . less more
RIDADR	UN 3271 3/PG 2
WGK Germany	1
F	21
Autoignition Temperature	155 °C
TSCA	Yes
HazardClass	3
PackingGroup	II
HS Code	29225000
Toxicity	LD50 orally in Rabbit: > 5000 mg/kg less more

Raw materials And Preparation Products

Hazard Information

Chemical Properties

clear colourless liquid

Uses

1,1-Dimethoxy-N,N-dimethylmethanamine is used as a reagent in the formation of pyridine derivatives that exhibit inhibition against PI3 kinase p110α enzymes.

Definition

ChEBI: An acetal obtained by formal condensation of N,N-dimethylformamide with methanol. N,N-dimethylformamide dimethyl acetal is a derivatisation agent used in gas-chromatography applica ions

General Description

Esterate M (N,N-Dimethylformamide dimethyl acetal, DMFDMA) is an methylating reagent. It has been used in methyl esterification of carboxylic acid and also in one-step derivatization of amino acids into N,N-Dimethylaminomethylene methyl esters.

Flammability and Explosibility

Highlyflammable

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations
reagent type: derivatization reagent
reaction type: Esterifications

Synthesis

124-41-4

68-12-2

4637-24-5

A method for synthesizing N,N-dimethylformamide dimethyl acetal, comprising the steps of (1) heating N,N-dimethylformamide to 70°C, mixing with dimethyl sulfate in a molar ratio of 1:1 and reacting for 4 hours after the end of dropwise addition to obtain the imine complex, and then cooling to room temperature; (2) adding solid sodium methanol to 200 solvent oil, dispersing it by ultrasonication, adjusting the temperature to 25 ℃ and maintained, dropwise addition of the imine complex, the reaction for 2 hours and then filtered, the filtrate often pressure fractionation, collection of 105-108 ℃ fraction, to obtain N,N-dimethylformamide dimethyl acetal, the yield was 75.3%, purity of 97%; wherein the molar ratio of sodium methanol to the imine complex is 1:1. The synthesis of the N,N-dimethylformamide dimethyl acetal of Example 6 is the same as that of Example 2, the The difference is that the organic solvent of this embodiment is a mixed solvent oil: D40 solvent oil, D60 solvent oil and 260 solvent oil, with a volume ratio of 2:1:1, to obtain N,N-dimethylformamide dimethyl acetal with a yield of 85.4% and a purity of 97%.

References

[1] Patent: CN106083611, 2016, A. Location in patent: Paragraph 0034-0037; 0048-0049

Material Safety Data Sheet(MSDS)

Spectrum Detail

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