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1118-68-9

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Identification

Name
N,N-Dimethylglycine
CAS
1118-68-9
Synonyms
AKOS BB-5614
(DIMETHYLAMINO)ACETIC ACID
DIMETHYLGLYCINE
DIMETHYLGLYCINE(N,N-)
DMG
N,N-DIMETHYLAMINOACETIC ACID
N,N-DIMETHYLGLYCINE
RARECHEM AL BO 0104
Glycine,N,N-dimethyl-
n,n-dimethyl-glycin
n-methylsarcosine
N,N-DIMETHYLGLYCINE FREE BASE
2-dimethylaminoacetic acid
N,N-Dimthylglycine
N,N-Dimethylglycine, 98+%
N,N-Dimethylglycine ,97%
EINECS(EC#)
214-267-8
Molecular Formula
C4H9NO2
MDL Number
MFCD00004283
Molecular Weight
103.12
MOL File
1118-68-9.mol

Chemical Properties

Appearance
white to slightly yellow crystalline powder
Melting point 
178-182 °C(lit.)

mp 
178-182 °C(lit.)

Boiling point 
193.35°C (rough estimate)
density 
1 g/cm3
refractive index 
1.4674 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
9.89(at 25℃)
form 
Crystalline Powder
color 
White to slightly yellow
Water Solubility 
soluble
Sensitive 
Hygroscopic
Detection Methods
T,NMR
Merck 
14,3244
BRN 
1700261
InChIKey
FFDGPVCHZBVARC-UHFFFAOYSA-N
CAS DataBase Reference
1118-68-9(CAS DataBase Reference)
EPA Substance Registry System
1118-68-9(EPA Substance)

Safety Data

Hazard Codes 
Xn,Xi
Risk Statements 
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements 
S24/25:Avoid contact with skin and eyes .
S36/37:Wear suitable protective clothing and gloves .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
WGK Germany 
3

RTECS 
MB9865000


3
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29224999

Raw materials And Preparation Products

Preparation Products
4-(IMIDAZOL-1-YL)PHENOL

Material Safety Data Sheet(MSDS)

Questions And Answer

Description
N,N-Dimethylglycine (DMG) is a N-methylated product of the amino acid glycine. It is found in beans and liver. It is used in comparative analysis with other N-methylated glycines. N,N-Dimethylglycine is used in the development of glycine-based ionic liquids and emulsifiers, and as a substrate to identify, differentiate and characterize amino acid methyltransferase(s). It can be used also as an athletic performance enhancer, immunostimulant, and to treat autism, epilepsy, or mitochondrial disease. N,N-Dimethylglycine is potentially useful as a biomarker of protein degradation in COPD patients.
References
J. K. Kern, V. S. Miller, L. Cauller, R. Kendall, J. Mehta, M. Dodd, Effectiveness of N,N-Dimethylglycine in Autism and Pervasive Developmental Disorder, Journal of Child Neurology, 2001, vol. 16, pp. 169-173

Hazard Information

Chemical Properties
white to slightly yellow crystalline powder
Uses
Dimethylglycine has been suggested for use as an athletic performance enhancer, immunostimulant, and a treatment for autism, epilepsy, or mitochondrial disease . Published studies on the subject have shown little to no difference between DMG treatment and placebo in autism spectrum disorders.
Definition
ChEBI: An N-methylglycine that is glycine carrying two N-methyl substituents.
Preparation
N,N-Dimethylglycine is commercially available as the free form amino acid, and as the hydrochloride salt [2491-06-7 ]. DMG may be prepared by the alkylation of glycine via the Eschweiler–Clarke reaction. In this reaction, glycine is treated with aqueous formaldehyde in formic acid that serves as both solvent and reductant. Hydrochloric acid is added thereafter to give the hydrochloride salt. The free amino acid may been obtained by neutralization of the acid salt, which has been performed with silver oxide.
H2NCH2COOH + 2 CH2O + 2 HCOOH →(CH3)2NCH2COOH + 2 CO2 + 2 H2O.
General Description
N,N-Dimethylglycine is a type of quaternary ammonium compound which exhibits a variety of biological effects.

Biochem/physiol Actions
N,N-Dimethylglycine (DMG) is a natural N-methylated glycine that is used in comparative analysis with other N-methylated glycines such as sarcosine and βine. N,N-Dimethylglycine is used in the development of glycine-based ionic liquids and emulsifiers. N,N-Dimethylglycine is potentially useful as a biomarker of protein degradation in COPD patients. DMG is used as a substrate to identify, differentiate and characterize amino acid methyltransferase(s).

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