4578-31-8

Adenosine 5'-monophosphate disodium salt(4578-31-8) is a modified phosphoramidite used for the synthesis of deoxyribonucleosides and nucleosides. Adenosine 5'-monophosphate disodium salt is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK). It may be used as a substrate by a variety of enzymes such as AMP-thymidine kinase, AMP deaminase and 5?-nucleotidase.

White powder

Adenosine 5'-monophosphate disodium salt(4578-31-8) is useful for skin rejuvenation in dermatology and aesthetic dermatology.

ChEBI: Adenosine 5'-phosphate disodium is an organic molecular entity.

Research indicates that an emulsion containing 3% Adenosine 5'-monophosphate disodium salt (AMP-NA2) safely accelerates human stratum corneum renewal. AMP-Na₂ exhibits dual characteristics in the proliferation of primary cultured keratinocytes: inducing cell growth at low concentrations whilst inhibiting it at high concentrations. It further promotes cell cycle progression in the basal layer of hairless rat epidermis. Research suggests topical AMP-Na₂ achieves mild penetration into the epidermal basal layer, where its low-concentration environment facilitates cell cycle advancement.
[1] FUKUMI FURUKAWA. Effects of adenosine 5′-monophosphate on epidermal turnover[J]. Archives of Dermatological Research, 2008, 300 9: 485-493. DOI:10.1007/s00403-008-0882-x.

Adenosine 5'-monophosphate disodium salt(AMP-2Na,4578-31-8) is an orally active purine nucleotide, and participates in ATP metabolism. AMP-2Na is also a ligand for adenosine 2B receptor. AMP-2Na can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. AMP-2Na can be used for research of diabetes.