(±)-Climbazole is an imidazole antifungal agent.
1 It inhibits the growth of
C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of
M. pachydermatis (MICs = <0.06-1 μg/ml) and
M. furfur (MICs = <0.06-0.5 μg/ml)
in vitro.
2,3,4 It also reduces the size of
Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo.
1 (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver.
5 Formulations containing climbazole have been used in the treatment of dandruff.
