303-38-8

Pale Brownish to Red Brownish Crystalline Powder

2,3-Dihydroxybenzoic Acid is a selected phenol as MMP (Matrix Metalloproteinase) inhibitor.

ChEBI: A dihydroxybenzoic acid that is benzoic acid substituted by hydroxy groups at positions 2 and 3. It occurs naturally in Phyllanthus acidus and in the aquatic fern Salvinia molesta.

2,3-Dihydroxybenzoic acid was found to be orally effective iron-chelating drug in hypertransfused rat model. It is monocatechol siderophore produced by Brucella abortus.

There are two main routes for the preparation of 2,3-dihydroxybenzoic acid (2,3-DHBA): chemical synthesis and biosynthesis. The classic chemical synthesis method is the carboxylation of catechol, similar to the Kolbe-Schmidt reaction. This method typically involves reacting catechol with an alkali metal salt (such as sodium or potassium salt) under high temperature (approximately 200°C) and high pressure (several megapascals) carbon dioxide atmosphere, resulting in the substitution of the ortho- and ortho-positions of the benzene ring with a carboxyl group (-COOH). Subsequent acidification yields the target product. Furthermore, with the development of green chemistry, biosynthesis has also become an important preparation method. For example, specific microorganisms or enzymes (such as the reverse reaction of 2,3-dihydroxybenzoic acid decarboxylase) can be used to achieve the carboxylation of catechol, or 2,3-dihydroxybenzoic acid can be prepared through the 3-hydroxylation of salicylic acid.

Store at -20°C