28399-50-0

Rabelomycin is an angucycline group antibiotic.

Rabelomycin is antibiotic, which exhibits antimicrobial activity against gram positive bacteria. Rabelomycin exhibits inhibitory activity against inducible nitric oxide synthase (iNOS) with an IC50 of 63.9 μM[1][2].

iNOS: 63.9 μM (IC₅₀)

[1] Kharel MK, et al., Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic. Org Lett. 2010 Jun 18;12(12):2814-7. DOI:10.1021/ol1009009
[2] Alvi K A, et al., Identification of inhibitors of inducible nitric oxide synthase from microbial extracts[J]. The Journal of Antibiotics, 2000, 53(5): 496-501.