ChemicalBook CAS DataBase List 23672-07-3

23672-07-3

Name	Levosulpiride
CAS	23672-07-3
EINECS(EC#)	233-599-4
Molecular Formula	C15H23N3O4S
MDL Number	MFCD00055220
Molecular Weight	341.43
MOL File	23672-07-3.mol

Synonyms

(-)-5-AMINOSULFONYL-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-2-METHOXY-BENZAMIDE LEVOSULPIRIDE (-)-N-1-[ETHYLPYRROLIDIN-2-YLMETHYL]-2-METHOXY-5-SULFAMOYLBENZAMIDE (S)-(-)-5-AMINOSULFONYL-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-2-METHOXYBENZAMIDE (S)-5-AMINOSULFONYL-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-2-METHOXYBENZAMIDE (S)-(-)-SULPIRIDE (-)-SULPIRIDE (s)-(-)-n-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide (s)-(-)-o-anisamid 5-(aminosulfonyl)-n-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-benzamid( levopraid rv-12309 s-(-)-n-(1-ethyl-2-pyrrolidinomethyl)-2-methoxy-5-sulfamoylebenzamide Levosulpride (S)-(-)-Sulpiride, Vetranal S(-)-SULPIRIDE DOPAMINE D1 ANTAGONIS LEVOSULPIRIDE/LEVOSULPRIDE Benzamide, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-, (S)- Benzamide, 5-(aminosulfonyl)-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-methoxy-(9CI) l-Sulpiride

Chemical Properties

Melting point	183-186 °C(lit.)
density	1.236±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMF (Slightly), DMSO (Slightly), Methanol (Slightly)
form	neat
pka	9.98±0.60(Predicted)
color	White to Off-White
Merck	13,9080
InChIKey	BGRJTUBHPOOWDU-NSHDSACASA-N
CAS DataBase Reference	23672-07-3(CAS DataBase Reference)

Safety Data

RIDADR	3077
WGK Germany	3
RTECS	BZ3400100
HS Code	29350090
Toxicity	LD50 oral in rabbit: > 1500mg/kg less more

Raw materials And Preparation Products

Hazard Information

Chemical Properties

White Solid

Uses

dopamine receptor antagonists

Uses

(S)-(?)-Sulpiride was used to study the effect of dopamine D₂ receptor function on activation of KCNQ potassium channels¹⁰ and on depression-like behavior in ovariectomized female rats.¹¹

Uses

Dopamine D2 and D3-receptor antagonist. Antipsychotic; antidepressant; antiemetic.

Definition

ChEBI: An optically active form of sulpiride having (S)-configuration. The active enantiomer of the racemic drug sulpiride. Selective D2-like dopamine antagonist (Ki values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 muM at D2, D3, D4, 1 and D5 receptors respectively).

General Description

(S)-(?)-Sulpiride is a levorotatory enantiomer of sulpiride, which shows greater central antidopaminergic activity, antiemetic and antidyspeptic effects. It is also used as a therapeutic drug for the treatment of depression and somatoform disorders.

Biological Activity

Active enantiomer. Selective D 2 -like dopamine antagonist (K i values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 μ M at D 2 , D 3 , D 4 , D 1 and D 5 receptors respectively).

Biochem/physiol Actions

(S)-(?)-Sulpiride or Levosulpiride blocks the inhibitory enteric D2 receptors (neuronal and muscular). It has prokinetic activity and is effective in the treatment of functional dyspepsia and gastroparesis in insulin-dependent diabetes mellitus patients.7,8 Since dopamine controls human sexual function, (S)-(?)-Sulpiride is reportedly effective in treatment of erectile dysfunctions.9

storage

Room temperature

Spectrum Detail

Well-known Reagent Company Product Information

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