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Echinulin is a diketopiperazine metabolite found in fungi that, when administered to rabbits, at a dose of 10 mg/kg, leads to liver and lung damage. It has no activity at the δ, κ, or μ-opioid receptors or the cannabinoid CB₁ and CB₂ receptors.

Echinulin is a metabolite of diketopiperazine.

ChEBI: Echinulin is an indole alkaloid with formula C29H39N3O2. It is a fungal metabolite found in several Aspergillus species. It has a role as an Aspergillus metabolite, a marine metabolite and a plant metabolite. It is a member of indoles, a member of 2,5-diketopiperazines, an olefinic compound and an indole alkaloid.

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[1] MUSLIM ALI . Toxicity of echinulin from Aspergillus chevalieri in rabbits[J]. Toxicology letters, 1989, 48 3: Pages 235-241. DOI: 10.1016/0378-4274(89)90049-0
[2] JIANGTAO GAO. Benzyl Derivatives with in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors from the Fungus Eurotium repens[J]. Journal of Natural Products , 2011, 74 7: 1636-1639. DOI: 10.1021/np200147c