ChemicalBook CAS DataBase List 1722-62-9

1722-62-9

Name	Mepivacaine hydrochloride
CAS	1722-62-9
EINECS(EC#)	217-023-9
Molecular Formula	C15H22N2O
MDL Number	MFCD00243006
Molecular Weight	246.35
MOL File	1722-62-9.mol

Synonyms

1-methyl-2',6'-pipecoloxylidine hydrochloride 1-METHYL-2',6'-PIPECOLOXYLIDINE HYDROCHLORIDE SALT LABOTEST-BB LT00134661 MEPIVACAINE MEPIVACAINE HCL MEPIVACAINE HYDROCHLORIDE n-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamide hydrochloride N-(2,6-DIMETHYLPHENYL)-1-METHYL-2-PIPERIDINECARBOXAMIDE HYDROCHLORIDE SALT (1-methyl-dl-piperidine-2-carboxylicacid)-2,6-dimethylanilidehydrochloride 1-methyl-2’,6’-pipecoloxylididehydrochloride 6’-pipecoloxylidide,1-methyl-2monohydrochloride carbocainehydrochloride dl-1-methyl-2’,6’-pipecoloxylididehydrochloride dl-mepivacainehydrochloride n-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamidmonohydrochloride MEPIVACAINE HYDROCHLORIDE, USP Mepivacaine HCl USP 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride 2',6'-Pipecoloxylidide, 1-methyl-, monohydrochloride (6CI, 8CI) 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride (9CI)

Chemical Properties

Melting point	255-257°C (dec.)
storage temp.	2-8°C
solubility	H2O: soluble20mg/mL, clear
form	powder
color	white to beige
CAS DataBase Reference	1722-62-9(CAS DataBase Reference)
EPA Substance Registry System	1722-62-9(EPA Substance)

Safety Data

Hazard Codes	Xn
Risk Statements	R22:Harmful if swallowed. less more
Safety Statements	S22:Do not breathe dust . S24/25:Avoid contact with skin and eyes . less more
RIDADR	UN 2811 6.1 / PGIII
RTECS	TK6475000
HS Code	29333990
Safety Profile	skin irritant. Questionable carcinogen with less more
Toxicity	LD50 in mice, rats (mg/kg): 280, 500 s.c. (Aberg) less more

Hazard Information

Chemical Properties

White Solid

Uses

An anti-inflammatory and analgesic

Uses

anesthetic (local)

Definition

ChEBI: The hydrochloride salt of mepivacaine. It is used as a local anaesthetic.

Brand name

Arestocaine Hydrochloride (Solvay Pharmaceuticals); Carbocaine (Hospira); Isocaine Hydrochloride(Novocol); Polocaine (AstraZeneca); Polocaine (Dentsply); Scandonest (Deproco).

Biological Functions

Mepivacaine hydrochloride (Carbocaine) is longer acting than lidocaine and has a more rapid onset of action (3–5 minutes). Topical application is not effective. It has been widely used in obstetrics, but its use has declined recently because of the early transient neurobehavioral effects it produces. Adverse reactions associated with mepivacaine are generally similar to those produced by other local anesthetics. It can be used with epinephrine or levonordefrin (dental use only).

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Mepivacaine hydrochloride is a local anesthetic that is related chemically and pharmacologically to the amide-type local anesthetics. It is often administered via local infiltration, peripheral nerve block, etc.

Biochem/physiol Actions

Local anesthetic. Reversibly blocks transient Na+ inward current, as well as the steady-state K+ outward current. Blocks tandem pore (TASK) and Kv1.5, potassium channels in model systems.

Spectrum Detail

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