16845-16-2

White crystalline powder, soluble in chloroform, derived from the dried rhizome of Acanthopanax senticosus.

Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human influenza virus efficacy, with an IC50?value of 64-125?μg/ml. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities[1].

Eleutheroside B1, a coumarin compound, has broad-spectrum anti-human influenza virus (influenza virus) activity with IC50 values of 64-125μg/ml. It mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits mRNA expression of multiple chemokine genes and influenza virus nucleoprotein (NP) gene with low cytotoxicity. Has antiviral and anti-inflammatory activity.

[1] Yan W, et al. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation.Int J Mol Med.?2018?Nov;42(5):2776-2792. DOI:10.3892/ijmm.2018.3863