ChemicalBook CAS DataBase List 39432-56-9

39432-56-9

Name	Eleutheroside E
CAS	39432-56-9
EINECS(EC#)	609-679-3
Molecular Formula	C34H46O18
MDL Number	MFCD00210498
Molecular Weight	742.72
MOL File	39432-56-9.mol

Chemical Properties

Melting point	269～270℃
Boiling point	935.7±65.0 °C(Predicted)
density	1.474±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO (Slightly), Ethyl Acetate (Slightly), Pyridine (Slightly, Sonicated)
form	Solid
pka	12.45±0.70(Predicted)
color	White to Off-White
Stability:	Hygroscopic
Major Application	food and beverages
InChIKey	FFDULTAFAQRACT-MDXYHMFDNA-N
SMILES	COc1cc(cc(OC)c1O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]3OC[C@@H]4[C@@H]3CO[C@H]4c5cc(OC)c(O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c(OC)c5

Safety Data

Hazard Codes	Xn
Risk Statements	22 less more
Safety Statements	24/25 less more
WGK Germany	3
HS Code	29389090
Storage Class	11 - Combustible Solids

Hazard Information

Chemical Properties

White crystalline powder, easily soluble in water, derived from Acanthopanax senticosus.

Uses

Eleutheroside E is used in the treatment of collagen-induced arthritis. Used in the suppression of inflammatory cytokine release. Successful in the treatment of rheumatoid arthritis. Also used in the regulation of adipogenesis

Definition

ChEBI: Eleutheroside E is a lignan and a glycoside.

in vivo

Eleutheroside E (0.003%, oral, daily, for five weeks) improves liver glucose metabolism in obese type 2 diabetes mice by upregulating glycolysis and downregulating gluconeogenesis^[1].
Eleutheroside E (15-60 mg/kg, oral, once daily, three weeks) alleviates arthritis in a collagen-induced arthritis mouse model^[3].
Eleutheroside E (50 mg/kg, oral, once daily, four weeks) prevents cognitive deficits caused by radiation in mice^[4].

Animal Model:	db/db mice^[1]
Dosage:	Containing 0.003% of the diet; 5 weeks
Administration:	Oral
Result:	Improved blood lipids, significantly reduced blood sugar and serum insulin levels, induced HOMA-IR, increased insulin sensitivity, and protected pancreatic α and β cells from diabetic damage.

Animal Model:	Collageninduced arthritis (CIA) mice^[3]
Dosage:	15, 30, 60 mg/kg; daily; 3 weeks
Administration:	Oral
Result:	Reduced mean arthritis score and arthritis incidence, reduced inflammatory cell infiltration, mesenchymal formation, cartilage damage and bone erosion in CIA mice, and decreased TNF-α and IL-6.

Animal Model:	Mice irradiated with 60Co-γ rays^[4]
Dosage:	50 mg/kg; daily; 4 weeks
Administration:	Oral
Result:	Improved cognitive and spatial memory impairments in irradiated mice, protected hippocampal neurons, and activated the PKA/CREB/BDNF signaling pathway.

target

NF-kB | TNF-α | IL Receptor | P450 (e.g. CYP17) | IFN-γ

Spectrum Detail

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