4-deoxy Pyridoxine (DOP) is a vitamin B
6 antimetabolite with diverse biological activities.
1,2,3,4,5 It inhibits transport of pyridoxine (Item No.
20706), pyridoxal, and pyridoxamine in and reduces growth of
S. carlsbergensis cells.
1 DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.
2 DOP (5 mg, i.p.) reduces lysyl oxidase activity by 26% and reduces collagen and elastin crosslinking, resulting in limb abnormalities in chick embryos.
3 It decreases latency to first seizure in mice (ED
50 = 1 mmol/kg) and increases the occurrence and duration of myoclonic responses in baboons with photosensitive epilepsy.
4 DOP reduces TNF-α and IL-6 production in mice infected with
T. spiralis.
5 
