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1405-86-3

Name Glycyrrhizic acid
CAS 1405-86-3
EINECS(EC#) 215-785-7
Molecular Formula C42H62O16
MDL Number MFCD00065194
Molecular Weight 822.93
MOL File 1405-86-3.mol
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Chemical Properties

Melting point  220°C (rough estimate)
alpha  D17 +46.2° (c = 1.5 in alc)
Boiling point  681.01°C (rough estimate)
density  1.1442 (rough estimate)
refractive index  61 ° (C=1.5, EtOH)
storage temp.  Inert atmosphere,2-8°C
solubility  DMSO (Slightly), Ethanol (Slightly), Methanol (Sparingly), Pyridine (Slightly)
form  Solid
pka 2.76±0.70(Predicted)
color  White to Light Yellow
Odor at 100.00 %. mild spicy
Odor Type spicy
Merck  4505
Stability: Hygroscopic
InChIKey BXFBITNYMHAJGT-KYXJNIQISA-N
LogP 4.64
Uses
Glycyrrhizin is a flavorant and foaming agent derived from the separation of flavonoids found in the whole licorice extract from the licorice root glycyrrhiza glabra. It is 50–100 times as sweet as sugar, is soluble in water, and has a licorice taste. It has good heat stability but prolonged heating can result in some degradation. It is stable within ph 4–9; below ph 4 there could be precipitation. It has foaming and emulsifying properties in water, being used in cocktail mixes and soft drinks. It is used as a flavorant in bacon and imitation whipped products. It is synergistic with sugar, the sweetness being amplified to 100 times that of cane sugar alone. It is used as a sweetener in sugar-free chewing gum and low-fat sugar-free frozen desserts. It is also termed ammoniated glycyrrhizin. Monoammonium glycyrrhizinate is obtained by additional refinement.
CAS DataBase Reference 1405-86-3
EPA Substance Registry System .alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-(1405-86-3)
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Safety Data

Safety Statements 
WGK Germany  3
RTECS  MD2025000
HS Code  29389000
Safety Profile
Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by ingestion: somnolence and changes in the metabolism of phosphorus, When heated to decomposition it emits acrid smoke and irritating fumes.
Hazardous Substances Data 1405-86-3(Hazardous Substances Data)
Toxicity
human,TDLo,oral,5571ug/kg/3D- (5.571mg/kg),KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION,Toxicologist. Vol. 54, Pg. 109, 2000.

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