ChemicalBook CAS DataBase List 13422-51-0

13422-51-0

Name	Hydroxocobalamin
CAS	13422-51-0
EINECS(EC#)	236-534-8
Molecular Formula	C62H90ClCoN13O15P
MDL Number	MFCD00167463
Molecular Weight	1382.82
MOL File	13422-51-0.mol

Chemical Properties

Definition	A form of vitamin B 12.
Melting point	>300 °C
storage temp.	2-8°C
solubility	methanol: 10 mg/mL at 20 °C, clear, dark red
form	neat
color	Dark Brown to Black
Odor	odorless
Stability:	Hygroscopic
Major Application	pharmaceutical (small molecule)
InChIKey	YOZNUFWCRFCGIH-ZKJXODNJNA-K
LogP	-2.812 (est)
EPA Substance Registry System	Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with (5,6-dimethyl-1-.alpha.-D- ribofuranosyl-1H-benzimidazole-. kappa.N3)(13422-51-0)

Safety Data

Hazard Codes	Xi
Risk Statements	36/37/38 less more
Safety Statements	26-36 less more
WGK Germany	3
RTECS	GG3820000
F	3-8-10
TSCA	TSCA listed
Storage Class	11 - Combustible Solids
Hazardous Substances Data	13422-51-0(Hazardous Substances Data)
Toxicity	LD50 intravenous in mouse: > 50mg/kg less more

Raw materials And Preparation Products

Hazard Information

Uses

Vitamin (hematopoietic).

Originator

Alpha-Redisol,MSD,US,1962

Manufacturing Process

A solution containing 26.3 mg of vitamin B12 in 15 ml of water was shaken with 78 mg of platinum oxide catalyst and hydrogen gas under substantially atmospheric pressure at 25°C for 20 hours. Hydrogen was absorbed. During the absorption of hydrogen the color of the solution changed from red to brown. The solution was separated from the catalyst and evaporated to dryness in vacuo. The residue was then dissolved in 1 ml of water and then diluted with about 6 ml of acetone.
After standing for several hours a small amount of precipitate (about 2 to 3 mg) was formed and was then separated from the solution. This solution was diluted with an additional 2 ml of acetone and again allowed to stand for several hours. During this time about 4 to 5 mg of noncrystalline precipitate formed. This solid was separated from the solution and an additional 2 ml of acetone was added to the solution. On standing, vitamin B12a began to crystallize in the form of red needles. After standing for 24 hours, the crystalline material was separated, yield 12 mg. By further dilution of the mother liquor with acetone additional crystalline precipitate formed (from US Patent 2,738,302).

Therapeutic Function

Hematopoietic vitamin

Side effects

Hydroxocobalamin is generally a well-tolerated drug. The adverse effects stem from hypersensitivity reactions to cobalt or other components of the hydroxocobalamin injection. These adverse effects include; exanthema (rash), Itching, fever, nausea, dizziness, rigors, and hot flushes. Anaphylaxis is rare.

Material Safety Data Sheet(MSDS)

Questions And Answer

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