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79-81-2

Name Retinol palmitate
CAS 79-81-2
EINECS(EC#) 201-228-5
Molecular Formula C36H60O2
MDL Number MFCD00019414
Molecular Weight 524.86
MOL File 79-81-2.mol

Chemical Properties

Melting point  28-29℃
Boiling point  546.51°C (rough estimate)
density  0.9668 (rough estimate)
refractive index  1.5250 (estimate)
Fp  194℃
storage temp.  2-8°C
solubility  Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
form  oil
color  Light Yellow to Yellow Low Melting
Specific Gravity 0.90~0.93 (20℃)
Water Solubility  Soluble in chloroform, ether, and vegetable oils. Insoluble in water.
Merck  13,10073
BRN  1917366
BCS Class 4
Stability: Light Sensitive
InChIKey VYGQUTWHTHXGQB-YFAKFODJSA-N
LogP 15.51 at 25℃
Uses
retinyl palmitate(79-81-2) is a skin conditioner. This retinoid is considered a milder version of retinoic acid, given its conversion properties. once on the skin, it converts to retinol, which in turn converts to retinoic acid. Physiologically, it is credited with increasing R epidermal thickness, stimulating the production of more epidermal protein, and increasing skin elasticity. Cosmetically, retinyl palmitate is used to reduce the number and depth of fine lines and wrinkles, and prevent skin roughness resulting from uV exposure. Secondary reactions such as erythema, dryness, or irritation are not associated with retinyl palmitate. It is even more effective when used in combination with glycolic acid because it achieves greater penetration. In the united States, its maximum usage level in cosmetic formulations is 2 percent. Retinyl palmitate is the ester of retinol and palmitic acid.
CAS DataBase Reference 79-81-2(CAS DataBase Reference)
NIST Chemistry Reference Vitamin a palmitate(79-81-2)
EPA Substance Registry System 79-81-2(EPA Substance)

Safety Data

Hazard Codes  T,Xn
Risk Statements 
R63:Possible risk of harm to the unborn child.
Safety Statements 
S53:Avoid exposure-obtain special instruction before use .
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37:Wear suitable protective clothing and gloves .
RIDADR  UN1170 - class 3 - PG 2 - Ethanol, solution
WGK Germany  3
RTECS  VH6860000
8-10-23
TSCA  Yes
HS Code  29362100
Safety Profile
Mildly toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Toxicity
LD50 (10 day) in mice, rats (mg/kg): 6060, 7910 orally (Kamm)

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