ChemicalBook CAS DataBase List 132203-70-4

132203-70-4

Name	Cilnidipine
CAS	132203-70-4
EINECS(EC#)	634-350-6
Molecular Formula	C27H28N2O7
MDL Number	MFCD00865853
Molecular Weight	492.52
MOL File	132203-70-4.mol

Synonyms

1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-METHOXYETHYL (2E)-3-PHENYL-2-PROPENYL ESTER ATELEC CILNIDIPINE CINALONG (+/-)-(e)-cinnamyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate FRC-8653 SISCARD (e)-(+-)-ethoxyethyl3-phenyl-2-propenyleste 5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-2-m Cinildipine CINILDPINE Cinidipine 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl Ester, FRC-8653, Atelec, Cinalong, Siscard, CILNIDPINE 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)-(+-)- clinidipine FRG 8653 Cilnidipine and intermediates

Chemical Properties

Appearance	Yellow Crystalline Solid
Melting point	97-99°C
Boiling point	652.6±55.0 °C(Predicted)
density	1.240±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	H2O: ≤2mg/mL
form	powder
pka	2.61±0.70(Predicted)
color	light yellow
Water Solubility	H2O: ≤2mg/mL DMSO: ≥20mg/mL
Usage	A dihydropyridine calcium channel blocker
Merck	14,2275
InChIKey	KJEBULYHNRNJTE-DHZHZOJOSA-N
SMILES	C1(C)NC(C)=C(C(OC/C=C/C2=CC=CC=C2)=O)C(C2=CC=CC([N+]([O-])=O)=C2)C=1C(OCCOC)=O
CAS DataBase Reference	132203-70-4(CAS DataBase Reference)

Safety Data

Hazard Codes	Xi
Risk Statements	41 less more
Safety Statements	26-39 less more
WGK Germany	3
RTECS	US7975550
HS Code	29333990
Toxicity	LD50 in male, female mice, rats (mg/kg): 5000, 5000, 5000, 4412 orally; 5000 all species s.c.; 1845, 2353, 441, 426 i.p. (Wada) less more

Raw materials And Preparation Products

Hazard Information

Chemical Properties

Yellow Crystalline Solid

Originator

Fujirebio (Japan)

Uses

A dihydropyridine calcium channel blocker

Uses

A dihydropyridine calcium channel blocker.

Uses

antihypertensive;dihydropyridine calcium channel blocker

Definition

ChEBI: A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.

Brand name

Cinalong;Siscard;Atelec

Biological Activity

Dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.

Biochem/physiol Actions

Cilnidipine is a slow-acting Ca2+ channel blocker; antihypertensive; vasodilator; dual blocker of L-type voltage-gated Ca2+ channels in vascular smooth muscle and N-type Ca2+ channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine may offer an advantage over nifedipine as the long term intake of the latter has been linked to increased risk of myocardial infarction and mortality in patients with coronary artery disease. Cilnidipine lowers blood pressure, but has less effect on sympathetic activity. Unlike nifedipine, cilnidipine does not inhibit PKC.

storage

4°C, protect from light

Material Safety Data Sheet(MSDS)

Questions And Answer

Spectrum Detail

Well-known Reagent Company Product Information

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132203-70-4

Chemical Properties

Safety Data

Raw materials And Preparation Products

Raw materials

Hazard Information

Chemical Properties

Originator

Uses

Uses

Uses

Definition

Brand name

Biological Activity

Biochem/physiol Actions

storage

Material Safety Data Sheet(MSDS)

Questions And Answer

Description

References

Spectrum Detail

Well-known Reagent Company Product Information

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