ChemicalBook CAS DataBase List 130-85-8

130-85-8

Name	Pamoic acid
CAS	130-85-8
EINECS(EC#)	204-998-0
Molecular Formula	C23H16O6
MDL Number	MFCD00004079
Molecular Weight	388.37
MOL File	130-85-8.mol

Synonyms

2,2'-DIHYDROXY-1,1'-DINAPHTHYLMETHANE 3,3'-DICARBOXYLIC ACID 4-[(3-CARBOXY-2-HYDROXY-NAPHTHALEN-1-YL)METHYL]-3-HYDROXY-NAPHTHALENE-2-CARBOXYLIC ACID 4-4'-METHYLENE-BIS-[2-HYDROXY-3-NAPHTHOIC ACID] 4,4'-METHYLENEBIS(3-HYDROXY-2-NAPHTHALENECARBOXYLIC ACID) 4,4-METHYLENEBIS[3-HYDROXY-2-NAPHTHALENECARBOXYLIC ACID] 4,4'-METHYLENEBIS(3-HYDROXY-2-NAPHTHOIC ACID) 4,4-METHYLENEBIS(3-HYDROXY-2-NAPHTHOIC ACID) 4,4'-METHYLENE BIS-(3-HYDROXY-2-NAPTHOIC ACID) EMBIONIC ACID EMBONIC ACID PAMOIC ACID 4,4’-methylenebis(3-hydroxy-2-naphthalenecarboxylicaci 4,4’-methylenebis(3-hydroxy-2-naphthoicaci 4,4’-methylenebis[3-hydroxy-2-naphthalenecarboxylicaci 3,3-dihydroxy-4,4-methylenedi(2-naphthoic acid) Embonic acid~4,4-Methylenebis(3-hydroxy-2-naphthoic acid) PAMOIC ACID FREE ACID PamoicAcid98% Pamoic 2-Naphthalenecarboxylic acid, 4,4-methylenebis3-hydroxy-

Chemical Properties

Appearance	yellow to yellow-green crystalline powder
Melting point	≥300 °C (dec.)
Boiling point	434.1°C (rough estimate)
density	1.2472 (rough estimate)
refractive index	1.4593 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in nitrobenzene, pyridine
form	Crystalline Powder
pka	2.67±0.30(Predicted)
color	Yellow to yellow-green
Water Solubility	PRACTICALLY INSOLUBLE
Merck	14,7005
BRN	901319
InChI	1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29)
InChIKey	WLJNZVDCPSBLRP-UHFFFAOYSA-N
SMILES	OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(O)=O)c1O
CAS DataBase Reference	130-85-8(CAS DataBase Reference)
EPA Substance Registry System	130-85-8(EPA Substance)

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P305+P351+P338-P261-P280a-P304+P340-P405-P501a
Hazard Codes	Xi,Xn
Risk Statements	R36/37/38:Irritating to eyes, respiratory system and skin . R48:Danger of serious damage to health by prolonged exposure. R41:Risk of serious damage to eyes. R37/38:Irritating to respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36:Wear suitable protective clothing . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S22:Do not breathe dust . less more
WGK Germany	3
RTECS	QL2180000
TSCA	Yes
REACH Registrations	Active
HS Code	29182990
Storage Class	11 - Combustible Solids
Toxicity	eye-rbt 100 mg MOD FCTOD7 20,573,82 less more

Raw materials And Preparation Products

Hazard Information

Chemical Properties

Pamoic acid is yellow to yellow-green crystalline powder

Uses

Agonist of the orphan G protein-coupled receptor GPR35: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Used as an inhibitor in the real-time fluorescence enzymatic characterization study of specialized human DNA polymerases.

Definition

ChEBI: Pamoic acid is a dicarboxylic acid. It is functionally related to a 2-naphthoic acid. It is a conjugate acid of a pamoate(2-).

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biological Activity

(1)Pamoic acid can inhibit Cas9 endonuclease activity. It effectively blocks bacterial or mammalian genome editing mediated by SpyCas9, SauCas9 or BE4 base editors at multiple endogenous gene loci. In addition, pamoic acid displays substrate competitive and PAM binding site occupancy mechanisms that selectively inhibit linear DNA cleavage compared to Cas9 cleavage of superhelical DNA. Importantly, pamoic acid pharmacologically modulates Cas9-mediated genome editing in mice.
(2)GPR35 activation by Pamoic acid may increase the phosphorylation of ERK1/2, which in turn initiates an anti-inflammatory signal by suppressing NF-κB-dependent inflammatory genes.

Safety Profile

Poison by intraperitoneal route. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Material Safety Data Sheet(MSDS)

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

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