120737-78-2

120737-77-1

120737-78-2

General procedure for the synthesis of tert-butyl 2-methylpiperazine-1-carboxylate from the compound (CAS: 120737-77-1): a mixture of tert-butyl (RS)-4-benzyl-2-methylpiperazine-1-carboxylate (3.41 g, 11.7 mmol), ethanol (125 mL), and Pearlman's catalyst (0.854 g, 6.08 mmol) was was hydrogenated overnight at 36 psi pressure at ambient temperature. Upon completion of the reaction, the mixture was filtered and the solids were washed sequentially with ethanol, dichloromethane (DCM) and methanol (MeOH). The filtrate and washings were combined, concentrated in vacuum, redissolved in dichloromethane, filtered again and concentrated in vacuum to give tert-butyl 2-methylpiperazine-1-carboxylate as a beige oil (2.0 g, 86% yield). The nuclear magnetic resonance (NMR) spectrum of the product was in agreement with the data reported in the literature (J. Org. Chem. 1995, 60, 4183).