127799-54-6

The general procedure for the synthesis of 1-Boc-2-methylhydrazine from 1-Cbz-2-Boc-1-methylhydrazine is as follows: 24.8 g (70.8 mmol) of 1-benzyl-2-tert-butyl-1-methylhydrazine-1,2-dicarboxylate was dissolved in 500 mL of ethanol at room temperature and standard atmospheric pressure, and 1.24 g of palladium (10% activated charcoal) was added as a catalyst for the hydrogenation reaction. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth to remove the catalyst and the filtrate was concentrated and dried under reduced pressure to give the product. The yield was 12.3 g with a purity of 48%, representing 57% of the theoretical yield.

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[5] Patent: US2016/52884, 2016, A1. Location in patent: Paragraph 0599-0600