ChemicalBook CAS DataBase List 118-00-3

118-00-3

Name	2-Amino-9-beta-D-ribofuranosyl-9H-purine-6-(1H)-one hydrate
CAS	118-00-3
EINECS(EC#)	204-227-8
Molecular Formula	C10H13N5O5
MDL Number	MFCD00010182
Molecular Weight	283.24
MOL File	118-00-3.mol

Synonyms

2-AMINO-9-BETA-D-RIBOFURANOSYL-9H-PURINE-6-(1H)-ONE 9-B-D-RIBOFURANOSYLGUANINE 9-[BETA-D-RIBOFURANOSYL]GUANINE D-GUANOSINE GR GUANINE-9-BETA-D-RIBOFURANOSIDE GUANINE RIBOSIDE GUANOSINE O-(BETA-D-RIBOFURANOSYL)GUANINE VERNINE 2(3H)-Imino-9-beta-D-ribofuranosyl-9H-purin-6(1H)-one 2-Amino-1,9-dihydro-9beta-d-ribofuranosyl-6H-purin-6-one 2-amino-inosin 6H-Purin-6-one, 2-amino-1,9-dihydro-9-beta-d-ribofuranosyl- 9-beta-d-ribofuranosyl-guanin beta-d-Ribofuranoside, guanine-9 Guanine, 9beta-d-ribofuranosyl- guanine-9,beta-d-ribofuranosid Guanozin Guo

Chemical Properties

Appearance	Crystalline
Melting point	250 °C (dec.) (lit.)
alpha	-62 º (c=3, in 0.1 N NaOH)
Boiling point	425.8°C (rough estimate)
density	1.3790 (rough estimate)
refractive index	-76 ° (C=1, 1mol/L NaOH)
storage temp.	Store at RT.
solubility	0.1 M NaOH: 0.1 g/mL, clear, slightly yellow
form	Powder
pka	pK1:1.9(＋1);pK2:9.25(0);pK3:12.33(OH) (25°C)
color	White to light yellow
Odor	Odorless
PH	2.14；9.03
biological source	synthetic
Optical Rotation	[α]20/D -73±2°, c = 1.5% in 1 M NaOH
Water Solubility	0.75 g/L (25 ºC)
λmax	256 (pH 0.7)；253，276 (pH 7)；256～266 (pH 11.3)
Merck	14,4566
BRN	625911
Cosmetics Ingredients Functions	OPACIFYING SKIN CONDITIONING
InChI	1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1
InChIKey	NYHBQMYGNKIUIF-UUOKFMHZSA-N
SMILES	[H]O[H].NC1=Nc2c(ncn2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1
LogP	-2.331 (est)
CAS DataBase Reference	118-00-3(CAS DataBase Reference)
NIST Chemistry Reference	guanosine(118-00-3)
EPA Substance Registry System	118-00-3(EPA Substance)

Safety Data

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301+P310
Hazard Codes	T,Xi
Risk Statements	R25:Toxic if swallowed. less more
Safety Statements	S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S24/25:Avoid contact with skin and eyes . S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) . less more
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	MF8750000
F	10-23
Hazard Note	Irritant
TSCA	Yes
HazardClass	6.1
PackingGroup	Ⅲ
HS Code	29349990
Storage Class	11 - Combustible Solids

Raw materials And Preparation Products

Hazard Information

Chemical Properties

White, crystalline powder; odorless; mild saline taste. Very slightly soluble in cold water; soluble in boiling water, dilute mineral acids, hot acetic acid, and dilute bases; insoluble in alcohol, ether, chloroform, and benzene.

Uses

A constituent of nucleic acids.

Definition

A NUCLEOSIDE present in DNA and RNA and consisting of guanine linked to D-ribose via a β-glycosidic bond.

Definition

ChEBI: A purine nucleoside in which guanine is attached to ribofuranose via a beta-N9-glycosidic bond.

General Description

Guanosine is an aromatic organic molecule and a purine nucleoside. It is present in the cerebrospinal fluid, intestinal cells, blood-brain barrier and in brain microvessels.

Biochem/physiol Actions

Guanosine nucleoside elicits cellular effect as the guanine-based purinergic system. It modulates glutamate uptake by glutamate transporters. It may have neuroprotective functionality in central nervous system disorders. Guanosine promotes neurite arborization, outgrowth, proliferation and differentiation. Administration of guanosine replenished GTP and elicits protective function in renal ischemic injury.

storage

4°C, protect from light

Purification Methods

It crystallises from water as a dihydrate. Dry it at 110o.[Beilstein 26/18 V 81.]

References

[1] Biochemistry & Analytical Biochemistry[C]. 1900: 0. DOI: 10.4172/2161-1009
[2] HANSON RICHARD W. Garber A J. Phosphoenolpyruvate carboxykinase. I. Its ce:role in gluconeogenesis[J]. American Journal of Clinical Nutrition, 1972, 25 10: Pages 1010-1021. DOI: 10.1093/ajcn/25.10.1010
[3] NEER E J. G proteins: critical control points for transmembrane signals.[J]. Protein Science, 1994, 3 1: 3-14. DOI: 10.1002/pro.5560030102
[4] T OHTA R E T S Sarkar. The role of guanosine 5’-triphosphate in the initiation of peptide synthesis. 3. Binding of formylmethionyl-tRNA to ribosomes.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1967, 58 4: 1638-1644. DOI: 10.1073/pnas.58.4.1638

Material Safety Data Sheet(MSDS)

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